Study of TGF- and INS-PI3K-AKT Pathway Proteins as Predictors of Postoperative Delirium in Older Adults With and Without Diabetes

What this Trial Is About

This research aims to explore the relationship between postoperative delirium POD and specific proteins related to the TGF- and INS-PI3K-AKT signaling pathways ADNP, MAP6, PGC-1 in patients with diabetes. It is a two-center, prospective, single-blind, observational clinical study involving diabetic and non-diabetic patients to better understand these protein levels and their connection to delirium after surgery. Participants are divided into two groups those with a history of diabetes for more than two years and elevated glycated hemoglobin, and those without diabetes and normal blood glucose. Before surgery, 3 milliliters of blood is collected from each participant. The samples are processed, stored at -80C, and tested for TGF- and the related proteins using ELISA. There is no intervention or treatment applied during the study. During the study, researchers analyze the correlation between preoperative plasma levels of these proteins and the occurrence of delirium within three days after surgery. Participants are elderly patients undergoing limited thoracic and abdominal tumor surgery, with assessments including blood sample collection and cognitive function tests. The study runs from May 2024 to June 2026, with safety and outcomes closely monitored throughout this period.

Predictive Effect of TGF-β and INS-PI3K-AKT Related Proteins for POD in Diabetes Patients