Actively Recruiting
A National Prospective Cohort for Pregnancies in Patients With Rare Vascular Anomalies: COGRare5 Study
Led by Hospices Civils de Lyon · Updated on 2026-03-11
400
Participants Needed
36
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a national prospective study to better understand pregnancy complications among women with rare multisystemic vascular diseases such as Heredity Hemorrhagic Telangiectasia, Marfan syndrome, primary lower limb lymphedema, superficial arteriovenous malformations, and cerebro-spinal arteriovenous malformations. These conditions can cause serious health risks for both mother and baby, and the study aims to improve prevention and reduce mortality by gathering scientific data to inform recommendations. Participants in this observational study will be women aged between 18 and 45 years who are pregnant or have given birth within the last month. The study involves telephone interviews using a questionnaire to collect detailed information about severe and specific obstetrical complications experienced during and after pregnancy. This approach allows researchers to gather prospective data on these rare vascular disorders in pregnancy. Women will be followed every three months for up to 21 months to monitor the occurrence of obstetrical complications. Data collection includes clinical, radiological, or molecular biology diagnoses of the vascular conditions. The study respects participants’ informed consent and oral non-opposition, with safety and legal considerations accounted for. This follow-up will help researchers understand risks and improve care for pregnant women with these rare vascular anomalies.
CONDITIONS
Brief Title
Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 2 18 years and 2 45 years at the time of inclusion
- Pregnant and/or having given birth less than 1 month (2 30 days)
- Clinically and/or radiological and/or molecular biology diagnosis of a rare vascular disease before or during pregnancy or one month after delivery
- Having been informed of all pertinent aspects of the study and provided oral non-opposition
You will not qualify if you...
- Any person not fulfilling the inclusion criteria or refusing to take part in the study
- Major under legal protection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (phone or in-person)
Duration - Up to 21 months
Participants are observed with periodic questionnaires about obstetrical complications during and after pregnancy.
Questionnaires every 3 months
Trial Site Locations
Total: 36 locations
1
Service de Médecine Interne et Maladies Vasculaires + Service Neuropédiatrie et neurochirurgie de l'enfant - CHU Angers
Angers, France, 49933
Actively Recruiting
2
Service de Médecine interne et immunologie clinique + Service de Médecine Vasculaire - Hôpital Saint André, CHU de Bordeaux
Bordeaux, France, 33075
Withdrawn
3
Service Pneumologie et Oncologie Thoracique - AP-HP Hôpital Ambroise Paré
Boulogne-Billancourt, France, 92104
Actively Recruiting
4
Centre de Référence pour la maladie de Rendu-Osler - Service Génétique Clinique - Hôpital Femme-Mère-Enfant - Hospices Civils de Lyon
Bron, France, 69677
Actively Recruiting
5
Service d'imagerie médicale - Neuroradiologie interventionnelle - Hôpital Neurologique P. Wertheimer - HCL
Bron, France, 69677
Withdrawn
6
Service d'Imagerie Pédiatrique et Fœtale et Consultation Pluridisciplinaire des Angiomes - Hôpital Femme-Mère-Enfant - HCL
Bron, France, 69677
Actively Recruiting
7
Service de Génétique, Hôpital Femme-Mère-Enfant
Bron, France, 69677
Actively Recruiting
8
Service de Médecine Vasculaire - Hôpital de la Côte de Nacre
Caen, France, 14033
Actively Recruiting
9
Service Médecine Interne Estaing CHU de Clermont-Ferrand - Hôpital d'Estaing
Clermont-Ferrand, France, 63000
Actively Recruiting
10
CHU Dijon Bourgogne - Hôpital François Mitterrand
Dijon, France
Actively Recruiting
11
Service de Médecine vasculaire et HTA - Hôpital Albert Calmette, CHRU de Lille
Lille, France, 59037
Actively Recruiting
12
Service Médecine interne - CHRU de Lille - Hôpital Claude Huriez
Lille, France, 59037
Actively Recruiting
13
CHU de Marseille - Hôpital de la Timone
Marseille, France, 13385
Actively Recruiting
14
Service Médecine Interne - Hôpital Saint-Eloi, CHU de Montpellier
Montpellier, France, 34295
Actively Recruiting
15
Service de neuroradiologie diagnostique et interventionnelle - CHU de Nancy, Hôpital St-Julien
Nancy, France, 54035
Actively Recruiting
16
Service de Médecine Interne-Médecine Vasculaire, CHU de Nantes - Hôtel Dieu
Nantes, France, 44093
Actively Recruiting
17
Unité de neuro-interventionnelle CHU Nice, Hôpital Pasteur 2
Nice, France, 06001
Actively Recruiting
18
Service de dermatologie, CHU de Nice - Hôpital l'Archet 2
Nice, France, 06202
Actively Recruiting
19
Service de Neuroradiologie - AP-HP - Paris (Hôpital Lariboisière)
Paris, France, 75010
Actively Recruiting
20
Service de Lymphologie - Hôpital Cognacq-Jay - Paris
Paris, France, 75015
Actively Recruiting
21
Service de Cardiologie - Hôpital Bichat, AP-HP
Paris, France, 75018
Actively Recruiting
22
Service de Neuroradiologie Interventionnelle - Fondation Adolphe de Rothschild
Paris, France, 75019
Actively Recruiting
23
Service Radiologie-pneumologie interventionnelle - Hôpital Tenon AP-HP
Paris, France
Actively Recruiting
24
Service de Génétique CHU de Poitiers
Poitiers, France, 86021
Actively Recruiting
25
Service de Pneumologie CHU de Rennes - Hôpital Pontchaillou
Rennes, France, 35033
Actively Recruiting
26
Unité de Génétique médicale, CHU de Rennes, Hôpital Sud
Rennes, France, 35203
Actively Recruiting
27
Service Médecine Interne - Médecine vasculaire - CHU de Rouen, Hôpital Charles Nicolle
Rouen, France, 76000
Withdrawn
28
Service de Médecine Vasculaire et Thérapeutique, Explorations Fonctionnelles Vasculaires - CHU de Saint-Etienne - Hôpital Nord
Saint-Etienne, France, 42055
Actively Recruiting
29
Clinique cardiologique et des maladies vasculaires CHU de Nantes, Hôpital G. R. LAENNEC
Saint-Herblain, France, 44800
Actively Recruiting
30
Service Maladies vasculaires - HTA - NHC Pôle Médico-chirurgicale cardio-vasculaire, CHU de Strasbourg - Hôpital Civil
Strasbourg, France, 67091
Actively Recruiting
31
CHU de Strasbourg, Hôpital de Hautepierre
Strasbourg, France, 67200
Actively Recruiting
32
Service de Neuroradiologie Interventionnelle - Hôpital Foch
Suresnes, France, 92151
Actively Recruiting
33
Service de Cardiologie _ Hôpital des Enfants (Purpan)
Toulouse, France, 31026
Actively Recruiting
34
Service de Médecine Interne + Service Médecine Vasculaire _ Hôpital RANGUEIL
Toulouse, France, 31059
Actively Recruiting
35
Service Pneumologie, Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de TOURS
Tours, France, 37044
Actively Recruiting
36
CHU de Nancy - Hôpitaux de Brabois
Vandœuvre-lès-Nancy, France, 54511
Withdrawn
Research Team
S
Sophie DUPUIS-GIROD, MD
A
Amal AYADI ROBERT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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