Actively Recruiting

Age: 18Years +
All Genders
ID05789953

Preventing Postoperative Pulmonary Complications Using a Machine Learning-Assisted Approach

Led by Britta Trautwein · Updated on 2026-05-08

512

Participants Needed

1

Research Sites

13 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Postoperative pulmonary complications (POPC) are common after general anesthesia and cause increased illness and death in surgical patients. This research aims to improve early detection of POPC by developing a machine learning algorithm that uses standard clinical data and lung ultrasound images collected after surgery. The study will include 512 adults undergoing planned surgery with general anesthesia to better predict who is at risk of developing these complications before symptoms appear. All patients will have their routine clinical data collected during surgery and will receive a standardized lung ultrasound in the recovery room. Follow-up clinical exams will occur on postoperative days 1, 3, and 7 to check for signs of POPC using standardized criteria. The collected data, including ultrasound images, will be used to train and evaluate a neural network-based machine learning model to predict postoperative lung complications. Participants will be monitored through clinical exams and lung sonography after surgery, with data stored securely for analysis. Researchers will measure the number of patients developing POPC by day 7 or discharge. The model's predictive accuracy will be compared to existing risk scores. This study may help improve patient outcomes by enabling earlier detection and targeted prevention of lung complications after surgery.

CONDITIONS

Brief Title

PrEventing PostoPERative Pulmonary Complications by Establishing a MachINe-learning assisTed Approach

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adult patients
  • Undergoing elective surgical procedure
  • Receiving general anesthesia
Not Eligible

You will not qualify if you...

  • Patients younger than 18 years of age
  • Outpatient surgery
  • Postoperative admission to intensive care unit

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person) to confirm eligibility before surgery

Diagnostic Evaluation

Duration - Immediately postoperative

Participants undergo standardized lung sonography in the recovery room after surgery to collect imaging data.

1 visit (in-person) in the recovery room after surgery

Long-term Monitoring

Duration - 7 days after surgery

Participants are visited on the ward on postoperative days 1, 3, and 7 for clinical examination to detect postoperative pulmonary complications.

3 visits (in-person) on postoperative days 1, 3, and 7

Trial Site Locations

Total: 1 location

1

University Hospital Ulm

Ulm, Germany, 89081

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Research Team

B

Britta Trautwein, MD

S

Simone Kagerbauer, PD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Published Research Related To This Trial

Postoperative Pulmonary Complications, Early Mortality, and Hospital Stay Following Noncardiothoracic Surgery: A Multicenter Study by the Perioperative Research Network Investigators.

Ana Fernandez-Bustamante, Gyorgy Frendl, Juraj Sprung...

https://pubmed.ncbi.nlm.nih.gov/27829093

Continuous positive airway pressure for treatment of respiratory complications after abdominal surgery: a systematic review and meta-analysis.

Gabriela P Ferreyra, Iacopo Baussano, Vincenzo Squadrone...

https://pubmed.ncbi.nlm.nih.gov/18362624

A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications.

T E F Abbott, A J Fowler, P Pelosi...

https://pubmed.ncbi.nlm.nih.gov/29661384

Do ARISCAT scores help to predict the incidence of postoperative pulmonary complications in elderly patients after upper abdominal surgery? An observational study at a single university hospital.

Jitsupa Nithiuthai, Arunotai Siriussawakul, Rangsinee Junkai...

https://pubmed.ncbi.nlm.nih.gov/34876228

Use of Machine Learning to Develop and Evaluate Models Using Preoperative and Intraoperative Data to Identify Risks of Postoperative Complications.

Bing Xue, Dingwen Li, Chenyang Lu...

https://pubmed.ncbi.nlm.nih.gov/33783520

The role of ultrasonographic lung aeration score in the prediction of postoperative pulmonary complications: an observational study.

Marcell Szabó, Anna Bozó, Katalin Darvas...

https://pubmed.ncbi.nlm.nih.gov/33446103

Second-order grey-scale texture analysis of pleural ultrasound images to differentiate acute respiratory distress syndrome and cardiogenic pulmonary edema.

Claudia Brusasco, Gregorio Santori, Guido Tavazzi...

https://pubmed.ncbi.nlm.nih.gov/33313979