Study of Blood Proteins to Help Diagnose Chronic Thromboembolic Pulmonary Hypertension in Adults PROTEO-CTEPH Study

What this Trial Is About

Chronic ThromboEmbolic Pulmonary Hypertension CTEPH is a rare but serious condition that can develop after a pulmonary embolism PE. It causes ongoing shortness of breath and is suspected when patients have lung scan perfusion defects and signs of pulmonary hypertension PH on transthoracic echocardiography TTE. This research aims to find a specific proteomic pattern in patients suspected of having CTEPH to improve diagnosis accuracy, as TTE alone may not be sufficient. Participants suspected of CTEPH will undergo standard right heart catheterization and give a blood sample for proteomic analysis at the start. For those confirmed with CTEPH, a second blood sample will be taken six months later. This study is observational and focuses on collecting data without experimental treatment interventions. Participants will be evaluated through lung scans, echocardiography, and right heart catheterization to confirm or rule out CTEPH. Blood samples will be analyzed for proteomic patterns at diagnosis and, if confirmed, again after six months. Researchers will also review hemodynamic data at diagnosis and follow-up. The study is expected to continue through May 2027, with participants monitored and data collected at these key points.

Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension