Why do women do worse after coronary artery bypass grafting?
Sanne A E Peters, Jolanda Kluin
https://pubmed.ncbi.nlm.nih.gov/34524421/Actively Recruiting
Led by Jennifer Breel · Updated on 2024-08-15
10000
Participants Needed
1
Research Sites
52 weeks
Total Duration
Researchers are studying the differences between females and males undergoing cardiac surgery to understand how sex-specific factors affect perioperative care and outcomes. The study focuses on various perioperative elements such as body weight adaptation, medical history, drug processing, blood transfusions, blood clotting, heart-lung machine use, heart function, medication needs, risk and outcome scores, as well as short-term and long-term morbidity and mortality. This research aims to identify factors that may cause worse outcomes in females after cardiac surgery and improve their care. The study compares female and male patients undergoing all types of cardiac surgery by collecting and analyzing a wide range of perioperative data. This observational study does not involve experimental treatments but reviews existing records of patients treated between January 1998 and June 2021 at a specific medical center. The goal is to build a database of perioperative parameters to find differences that may require tailored care pathways for females. Participants are patients aged 18 years and older who have undergone cardiac surgery during the specified period. The research team will evaluate mortality rates at multiple time points 30 days, 1 year, 5 years, and 20 years after surgery. They will also assess postoperative complications at 30, 90, and 365 days, and develop a predictive risk score based on composite outcomes within 30 days. This long-term follow-up aims to enhance understanding of sex-specific risks and improve recovery after cardiac surgery.
CONDITIONS
SEx-specific Differences in Cardiac Surgery Patients (SECS).
J
Jennifer S Breel, MSc
S
Susanne Eberl, PhD
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Jennifer Breel
Lead Sponsor
You may qualify if you...
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Hospital stay duration following surgery
Participants undergo cardiac surgery and receive immediate post-operative care.
Hospital visits during surgery and immediate recovery
Duration - Up to 20 years postoperatively
Participants are monitored for post-operative complications and mortality over short and long term after surgery.
Follow-up visits at 30 days, 90 days, 1 year, 5 years, and up to 20 years postoperatively
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Sanne A E Peters, Jolanda Kluin
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https://pubmed.ncbi.nlm.nih.gov/34776353/Leslie Cho, Melina R Kibbe, Faisal Bakaeen...
https://pubmed.ncbi.nlm.nih.gov/34606298/Lauren Kari Dixon, Ettorino Di Tommaso, Arnaldo Dimagli...
https://pubmed.ncbi.nlm.nih.gov/34520795/Jennifer Breel
Lead Sponsor