Actively Recruiting
Sustainable Diets and Cardiometabolic Health
Led by University of Copenhagen · Updated on 2025-12-24
180
Participants Needed
1
Research Sites
70 weeks
Total Duration
On this page
Sponsors
U
University of Copenhagen
Lead Sponsor
N
Novo Nordisk Foundation (NNF)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to investigate the effects of sustainable diets on traditional and novel cardiometabolic risk factors. The primary objective is: • To test the effects of a sustainable diet on traditional cardiometabolic risk factors, specifically, a metabolic health score. The secondary objectives are: * To test the effects of sustainable diets on blood lipids, inflammatory markers, glucose markers, and anthropometric and body composition markers. * To test the effect of sustainable diets on circulating metabolomic profiles. * To test the effects of sustainable diets on circulating proteomic profiles. Participants will receive dietary interventions of a sustainable health diet, namely the PHD diet (Planetary Health Diet), an ovo-lacto-vegetarian diet, or a habitual diet following general recommendations for a healthy diet without advice on consumption of animal products. The three-arm parallel RCT will involve adults (45-70 years old) at cardiovascular risk. The primary hypothesis is that targeted interventions to adopt sustainable diets will have beneficial effects on cardiometabolic biomarkers, metabolomic, and proteomic profiles, compared to the habitual diet in individuals at cardiovascular risk.
CONDITIONS
Official Title
Sustainable Diets and Cardiometabolic Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults between 45 and 70 years old
- Have at least two metabolic issues: large waist circumference, high blood pressure or on blood pressure medication, prediabetes, or abnormal blood lipids
- Not institutionalized and able to read and consent
- Willing to attend in-person study visits
- Have access to and are comfortable using a smartphone and computer or tablet with internet
- Understand Danish in writing and speaking
You will not qualify if you...
- Have a serious illness or cancer history in the past 5 years (except treated basal cell skin cancer or cervical in situ cancer)
- Diagnosed with diabetes, cardiovascular events, or atrial fibrillation
- Have psychiatric conditions or cognitive impairment
- Are current smokers or use nicotine products
- Have a BMI over 35 kg/m2
- Abuse alcohol or drugs or drink more than Danish guidelines allow
- Are pregnant or planning pregnancy within a year
- Not willing to consume chicken and fish or make dietary changes
- Have multiple food allergies affecting diet adherence
- Any other condition causing doubt about eligibility by the study team
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Nutrition, Exercise and Sports, University of Copenhagen. Rolighedsvej 26, DK-1958 Frederiksberg C.
Copenhagen, Copenhagen, Denmark, 1958
Actively Recruiting
Research Team
M
Marta Guasch-Ferré, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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