Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications.
E H van der Meij, I van der Waal
https://pubmed.ncbi.nlm.nih.gov/12969224Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
ID05973097
Clinical Study of Combined Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy
Led by Peking University Third Hospital · Updated on 2023-08-02
156
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Oral lichen planus (OLP) is a common chronic inflammatory condition affecting the mouth's lining, often causing white patches that can worsen to painful erosions. It is considered a precancerous condition caused by an autoimmune reaction involving T-lymphocytes. Currently, treatments only address symptoms, and no cure exists. This research aims to evaluate the combined effect of paeoniflorin, a traditional Chinese medicine compound, and photodynamic therapy for treating OLP. Participants will be randomly assigned to one of three treatment groups: daily capsules of total glucosides of paeony at 0.6 grams three times a day; photodynamic therapy involving applying a photosensitizer to lesions followed by laser diode treatment; or a combination of both treatments. This trial will assess whether combining these therapies improves outcomes compared to each alone. During the study, participants will be monitored for treatment effectiveness after one month and followed up for about a year to observe longer-term effects. Researchers will measure improvements in OLP symptoms and track safety. The study involves signing informed consent and includes evaluations of oral lesions and overall health throughout participation, which may last up to a year.
CONDITIONS
Brief Title
Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with oral lichen planus
- Male or female patients aged 18 years or older
- Patients willing to participate and able to provide signed informed consent
You will not qualify if you...
- Pregnant or breastfeeding women
- Patients with serious heart, lung, liver, kidney diseases, or tumors
- Patients unwilling to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 1 month
Participants receive treatment with total glucosides of paeony capsules, photodynamic therapy, or a combination of both for oral lichen planus.
Regular visits during the 1 month treatment period
Follow-up
Duration - Up to 1 year after treatment
Participants are assessed for curative effect through study completion, approximately 1 year after treatment.
Follow-up visits depending on participant progress
Trial Site Locations
Total: 1 location
1
Peking University Third Hospital
Beijing, China
Actively Recruiting
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Research Team
Z
Zhihui Zhang, Dr.
L
Lin Zeng
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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Published Research Related To This Trial
Effects of total glucosides from paeony (Paeonia lactiflora Pall) roots on experimental atherosclerosis in rats.
Jing Li, Chang Xun Chen, Yun Hui Shen
https://pubmed.ncbi.nlm.nih.gov/21453765Dexamethasone solution and dexamethasone in Mucolox for the treatment of oral lichen planus: a preliminary study.
Alessandro Villa, Vidya Sankar, Gus Bassani...
https://pubmed.ncbi.nlm.nih.gov/32220595Comparison of the effect of photodynamic therapy and topical corticosteroid on oral lichen planus lesions.
Fatemeh Lavaee, Maryam Shadmanpour
https://pubmed.ncbi.nlm.nih.gov/31478283Clinical observation on the treatment of oral lichen planus with total glucosides of paeony capsule combined with corticosteroids.
Leilei Zhou, Tianyi Cao, Yufeng Wang...
https://pubmed.ncbi.nlm.nih.gov/27129091