Study of Paeoniflorin and Photodynamic Therapy for Treating Oral Lichen Planus in Adults

What this Trial Is About

Oral lichen planus OLP is a common chronic inflammatory condition affecting the mouths lining, often causing white patches that can worsen to painful erosions. It is considered a precancerous condition caused by an autoimmune reaction involving T-lymphocytes. Currently, treatments only address symptoms, and no cure exists. This research aims to evaluate the combined effect of paeoniflorin, a traditional Chinese medicine compound, and photodynamic therapy for treating OLP. Participants will be randomly assigned to one of three treatment groups daily capsules of total glucosides of paeony at 0.6 grams three times a day photodynamic therapy involving applying a photosensitizer to lesions followed by laser diode treatment or a combination of both treatments. This trial will assess whether combining these therapies improves outcomes compared to each alone. During the study, participants will be monitored for treatment effectiveness after one month and followed up for about a year to observe longer-term effects. Researchers will measure improvements in OLP symptoms and track safety. The study involves signing informed consent and includes evaluations of oral lesions and overall health throughout participation, which may last up to a year.

Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy