Activation of human quadriceps femoris during isometric, concentric, and eccentric contractions.
N Babault, M Pousson, Y Ballay...
https://pubmed.ncbi.nlm.nih.gov/11717228Actively Recruiting
Phase Not Applicable
Age: 18Years - 70Years
All Genders
ID04607174
Measuring Voluntary Activation of the Quadriceps Femoris During Isokinetic Concentric Contractions with the Interpolated Twitch Technique in Subjects with Neuromotor Disorders
Led by Istituto Auxologico Italiano · Updated on 2024-10-24
20
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the voluntary activation of the quadriceps femoris muscle during subjectively maximal isometric and isokinetic concentric contractions in patients with various neurological and orthopedic conditions. The study focuses on how well muscle fibers are recruited during these contractions, especially since activation may be reduced in people with motor impairments such as hemiparesis post-stroke, multiple sclerosis, traumatic knee injuries, and knee osteoarthritis. The goal is to better understand muscle activation differences at varying joint rotation speeds in affected patients. Participants will perform isometric contractions at 40° knee flexion and isokinetic concentric contractions at an angular velocity of 100°/s using an isokinetic dynamometer. Voluntary activation will be measured using the interpolated twitch technique (ITT), which involves delivering electrical shocks to the muscle belly during contractions to assess whether all muscle fibers are recruited. The procedure includes three electric shocks during isometric contractions and shocks during continuous passive motion and isokinetic concentric contractions, first on the affected limb and then on the non-affected limb. During the study, participants will undergo testing of muscle activation with electrical stimulation and perform specific knee movements. Researchers will measure voluntary activation levels as the primary outcome on the first day. Participants must be able to understand instructions, perform the motor tasks, and have sufficient knee joint mobility. The study also includes safety monitoring for conditions like epilepsy and other health factors that may affect participation. Total participation duration details are not specified.
CONDITIONS
Brief Title
Voluntary Activation During Isokinetic Contractions in Subjects with Neuromotor Disorders
Who Can Participate
Age: 18Years - 70Years
All Genders
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years old
- Ability to sign the informed consent form
- Ability to understand instructions and complete the motor tasks
- Voluntary knee flexion-extension range of at least 70 degrees
- Maximal knee extension angle less than 30 degrees (0° = full extension)
You will not qualify if you...
- Pregnancy
- History of epilepsy
- Mini Mental State Examination score less than or equal to 27 out of 30
- Implanted electro-sensitive devices
- Orthopedic conditions limiting lower limb joint mobility or muscle strength
- Current treatment with oral anticoagulant therapy
- Medium or severe osteoporosis with femoral bone mineral density t-score less than -3.5
- Familiarity with the testing method
AI-Screening
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Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - 1 day
Participants undergo assessments measuring voluntary activation of the quadriceps femoris during specific isometric and isokinetic contractions using the interpolated twitch technique.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Istituto Auxologico Italiano
Milan, MI, Italy, 20121
Actively Recruiting
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Research Team
L
Luigi Tesio, MD, Full Professor
S
Stefano Scarano, MD, Research Fellow
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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Published Research Related To This Trial
Intersession reliability of the interpolated twitch technique applied during isometric, concentric, and eccentric actions of the human knee extensor muscles.
Martin Behrens, Florian Husmann, Martin Gube...
https://pubmed.ncbi.nlm.nih.gov/27935064Plyometric training improves voluntary activation and strength during isometric, concentric and eccentric contractions.
Martin Behrens, Anett Mau-Moeller, Karoline Mueller...
https://pubmed.ncbi.nlm.nih.gov/25766509Voluntary activation level and muscle fiber recruitment of human quadriceps during lengthening contractions.
J G M Beltman, A J Sargeant, W van Mechelen...
https://pubmed.ncbi.nlm.nih.gov/15075302Quadriceps activation failure as a moderator of the relationship between quadriceps strength and physical function in individuals with knee osteoarthritis.
G Kelley Fitzgerald, Sara R Piva, James J Irrgang...
https://pubmed.ncbi.nlm.nih.gov/14872454Comparison of techniques to determine human skeletal muscle voluntary activation.
Anastasia Zarkou, Scott Stackhouse, Stuart A Binder-Macleod...
https://pubmed.ncbi.nlm.nih.gov/28649011Effect of age on muscle activation and twitch properties during static and dynamic actions.
Melissa R Wilder, Jack Cannon
https://pubmed.ncbi.nlm.nih.gov/19229967Knee muscle isometric strength, voluntary activation and antagonist co-contraction in the first six months after stroke.
D J Newham, S F Hsiao
https://pubmed.ncbi.nlm.nih.gov/11394588