Yoga versus health education for persistent fatigue in patients with post-COVID-19 syndrome: protocol for a multicentre randomised controlled trial.
Holger Cramer, Lisa Mörchen, Jan Vagedes...
https://pubmed.ncbi.nlm.nih.gov/41130694Actively Recruiting
Phase Not Applicable
Age: 18Years - 65Years
All Genders
ID05890599
Randomized Multicenter Clinical Trial: Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome
Led by University Hospital Tuebingen · Updated on 2025-07-10
100
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
Sponsors
U
University Hospital Tuebingen
Lead Sponsor
R
Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to evaluate the short- and medium-term effects of a yoga program compared to health education on fatigue in adults with post COVID-19 syndrome. The study focuses on patients experiencing persistent fatigue for at least 12 weeks following confirmed COVID-19 infection. The trial is designed to understand how these interventions may impact fatigue and related symptoms in this population. Participants are randomly assigned to one of two 12-week programs. The yoga group attends one 90-minute session per week and is encouraged to practice yoga themselves twice weekly for 30 minutes. The yoga therapy includes postures, breathing techniques, and relaxation exercises aimed at addressing fatigue symptoms and improving respiratory function. The health education group also receives weekly 90-minute sessions covering topics like post-COVID syndrome, stress management, nutrition, sleep hygiene, exercise, and coping strategies, along with similar self-practice schedules. Throughout the study, participants are monitored at 12 and 24 weeks for changes in fatigue levels, quality of life, psychological symptoms, sleep quality, stress, body awareness, and self-efficacy. Additional assessments include physical strength, movement tracking, heart rate variability, and blood markers. Safety is tracked regularly, and cost questionnaires are completed. The total participation includes baseline assessments and follow-ups over 24 weeks to capture both immediate and lasting effects of the interventions.
CONDITIONS
Brief Title
Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome
Who Can Participate
Age: 18Years - 65Years
All Genders
Eligibility Criteria
You may qualify if you...
- Confirmed COVID-19 diagnosis
- Follow-up symptoms lasting 12 weeks or more
- Persistent fatigue with a score of 4 or higher on the binomial Chalder Fatigue Scale
- Self-assessment that fatigue resulted from COVID-19
- Age between 18 and 65 years
You will not qualify if you...
- Chronic medical conditions or regular use of medications associated with fatigue
- Fatigue caused by health conditions other than post-COVID syndrome
- Other main causes of fatigue identified
- Physical limitations preventing participation in yoga
- Pregnancy or breastfeeding
- Participation in other clinical trials
- Current yoga practice
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Outpatient Treatment
Duration - 12 weeks
Participants engage in either a yoga therapy program or a health education program designed to treat persistent fatigue. The yoga therapy includes yoga postures, breathing techniques, and relaxation, while the health education program consists of weekly lectures and discussions on post-COVID syndrome and fatigue management.
Weekly sessions of 90 minutes each, plus self-practice twice weekly for 30 minutes
Trial Site Locations
Total: 1 location
1
Bosch-Health-Campus
Stuttgart, Germany, 70376
Actively Recruiting
Loading map...
Research Team
H
Holger Cramer, Professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here