Study of Immune and Blood Activation in Adults With Chronic Kidney Disease Undergoing Dialysis or Not

What this Trial Is About

This research investigates how patients with chronic kidney disease CKD undergoing hemodialysis HD are affected by bloodstream infections, particularly those caused by Staphylococcus aureus. HD patients face a very high risk of death, especially early after infection, largely due to cardiovascular problems and infections like endocarditis. The study aims to understand how HD may weaken the immune response and promote blood clotting that supports bacterial growth, increasing infection risks. The study collects blood samples from four groups CKD patients on hemodialysis, CKD patients not on dialysis, CKD patients on peritoneal dialysis, and healthy volunteers. Blood plasma is analyzed before and after HD sessions to measure inflammation and coagulation markers. The study compares these levels across groups to explore the effects of HD on immune activity and blood clotting. Participants will provide blood samples at enrollment and during HD sessions. Researchers will measure plasma levels of activated contact system markers, especially cHK, to assess immune and coagulation status. The study focuses on understanding blood changes related to infections and clotting in CKD and dialysis patients. Participation involves blood draws and health assessments, with data collected to improve knowledge about infection risks and immune function in this population.

Activation of the Contact System and the Immune System in Patients With Chronic Kidney Disease.