Evaluating Aerobic Exercise as an Addition to Antidepressant Therapy for Depression Treatment in South Punjab Pakistan
Led by Manahil Gill · Updated on 2026-09-17
66
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What This Trial Is About
Researchers are evaluating the effects of aerobic exercise as an additional therapy for adults with moderate to severe depressive disorder. This study compares two groups over 6 weeks to see how depression severity changes. One group receives standard antidepressant medication Sertraline and psychotherapy, while the other group receives the same medication and therapy plus structured aerobic exercises like cycling and brisk walking.
Participants in the experimental group will take part in supervised aerobic exercise sessions lasting 35 minutes each, three times per week for 6 weeks along with their usual treatment. The comparison group will receive only the standard treatment with antidepressants and psychotherapy. After 6 weeks, both groups will be assessed for changes in depression severity using the Beck Depression Inventory BDI scale.
During the study, participants will attend supervised exercise sessions if assigned to the exercise group and continue their medications and therapy. Researchers will measure the change in BDI scores from the start of the study to week 6 to evaluate depression severity. The study includes adults aged 18 to 55 of both genders, and monitoring will ensure safety and adherence throughout the 6-week period.
CONDITIONS
Brief Title
Aerobic Exercise as an Adjunct Therapy for Depression
Research Team
M
Manahil Gill, MBBS
M
Muhammad Ahsan Mustafa, MBBS
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New patients diagnosed with moderate or severe depression using the BDI scale and ICD-11 criteria
Aged between 18 and 55 years
Both male and female participants are eligible
You will not qualify if you...
Severe physical disabilities such as spinal cord injuries or severe osteoporosis that prevent exercise
Medical conditions preventing exercise like ischemic changes in ECG before exercise
Pregnant females
Individuals already engaged in regular physical activities like athletes
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 6 weeks
Participants receive either standard antidepressant medication and psychotherapy alone or combined with supervised aerobic exercise sessions three times per week for 35 minutes each.
Weekly supervised exercise sessions for the experimental group
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Evaluating Aerobic Exercise as an Addition to Antidepressant Therapy for Depression Treatment in South Punjab Pakistan
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Published Research Related To This Trial
Aerobic exercise or stretching as add-on to inpatient treatment of depression: Similar antidepressant effects on depressive symptoms and larger effects on working memory for aerobic exercise alone.
Christian Imboden, Markus Gerber, Johannes Beck...