Study of Hearing and Cerebrospinal Fluid in Adults Aged 20 to 40 With Multiple Sclerosis or Healthy Controls

What this Trial Is About

Researchers are investigating auditory functions in patients with Multiple Sclerosis MS by using various hearing tests and analyzing cerebrospinal fluid CSF for inflammatory markers. This observational case-control study compares healthy adults and adults with Relapsing Remitting MS, aiming to find correlations between auditory test results and CSF findings to better understand hearing issues related to MS. Participants will undergo several auditory tests including Pure Tone Auditory test, Tympanometry, Stapedial Reflex, Speech Perception test, and if applicable, tinnitus-related questionnaires and acuphenometry. Additionally, Distortion Product Otoacoustic Emissions DPOAEs and Auditory Brain Response ABR tests will be performed. CSF will be collected via lumbar puncture for analysis. MRI tractography is performed if hearing impairment is detected. Participants involvement includes screening through medical records, MRI scans, blood tests, and hearing loss questionnaires. They will undergo the auditory tests and CSF sampling as described. Researchers will measure auditory function and its correlation with CSF results over 12 months. The study includes healthy volunteers and MS patients aged 20 to 40 years, with ongoing monitoring of auditory function and neurological status.

Auditory Functions in Patients With Multiple Sclerosis