Actively Recruiting
Electrophysiological Studies of Auditory Functions and CSF Analyses in Patients With Multiple Sclerosis
Led by University of Catania · Updated on 2026-05-12
30
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
U
University of Catania
Lead Sponsor
H
Hannover Medical School
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating auditory functions in patients with Multiple Sclerosis (MS) by using various hearing tests and analyzing cerebrospinal fluid (CSF) for inflammatory markers. This observational case-control study compares healthy adults and adults with Relapsing Remitting MS, aiming to find correlations between auditory test results and CSF findings to better understand hearing issues related to MS. Participants will undergo several auditory tests including Pure Tone Auditory test, Tympanometry, Stapedial Reflex, Speech Perception test, and if applicable, tinnitus-related questionnaires and acuphenometry. Additionally, Distortion Product Otoacoustic Emissions (DPOAEs) and Auditory Brain Response (ABR) tests will be performed. CSF will be collected via lumbar puncture for analysis. MRI tractography is performed if hearing impairment is detected. Participants' involvement includes screening through medical records, MRI scans, blood tests, and hearing loss questionnaires. They will undergo the auditory tests and CSF sampling as described. Researchers will measure auditory function and its correlation with CSF results over 12 months. The study includes healthy volunteers and MS patients aged 20 to 40 years, with ongoing monitoring of auditory function and neurological status.
CONDITIONS
Brief Title
Auditory Functions in Patients With Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 and under 50 years
- No history of hearing loss
- No psychiatric conditions
- No family history of otosclerosis, deafness, or genetic hearing loss
- Diagnosis of Parkinson's disease and/or Multiple Sclerosis
You will not qualify if you...
- Conductive hearing loss
- Stroke within the last 2 years
- Uncontrolled cardiovascular disease
- Diabetes
- Hypotensive disorders
- Alcohol abuse
- Recreational drug use
- Epilepsy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 12 months
Participants undergo auditory tests including Pure Tone Auditory test, Tympanometry and Stapedial Reflex, Speech Perception test, and additional assessments if tinnitus is present. Cerebrospinal Fluid is collected by lumbar puncture for analysis.
1 to 2 visits including auditory tests and lumbar puncture
Duration - Single visit as needed
For participants with hearing impairment, MRI tractography is performed to assess auditory pathways.
1 visit (in-person) if hearing impairment is detected
Duration - 12 months
Participants are observed for auditory functions and their correlation with cerebrospinal fluid findings over 12 months.
Follow-up assessments as scheduled
Trial Site Locations
Total: 1 location
1
Arianna Di Stadio
Catania, Sicily, Italy, 95121
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here