Actively Recruiting
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study
Led by University of Wisconsin, Madison · Updated on 2026-01-15
660
Participants Needed
12
Research Sites
269 weeks
Total Duration
On this page
Sponsors
U
University of Wisconsin, Madison
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID). 575 participants will be enrolled and can expect to be on study for up to 5 years.
CONDITIONS
Official Title
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must be at least 18 years old
- Positive NOTCH3 genetic testing; OR a positive skin biopsy; OR willingness to have a NOTCH3 genetic test before enrolling AND are at-risk for or diagnosed clinically with CADASIL
- Willing to commit to three in-person visits (baseline, 18-month, and 36-month follow-ups) and remote visits as needed
- Willing to provide documentation of all current medications
- Willing and able to undergo MRI scans and blood draws at each in-person visit
- Must have a designated study companion who knows the participant well (3+ hours/month contact)
- Functional capacity less than 4 on the Modified Rankin Scale
- Healthy controls must meet the same criteria except have negative NOTCH3 genetic testing
You will not qualify if you...
- History of severe learning disability, intellectual disability, or other neurological disease or event not caused by CADASIL
- History of serious alcohol or drug abuse within the past year
- Unwilling to undergo NOTCH3 genetic testing if no prior test is available
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 12 locations
1
University of California
Los Angeles, California, United States, 90095
Actively Recruiting
2
University of California
San Francisco, California, United States, 94143
Actively Recruiting
3
University of Colorado
Denver, Colorado, United States, 80204
Actively Recruiting
4
Georgia State University Research Foundation
Atlanta, Georgia, United States, 30303
Actively Recruiting
5
Loyola University
Chicago, Illinois, United States, 60660
Actively Recruiting
6
Columbia University
New York, New York, United States, 10027
Actively Recruiting
7
Oregon Health & Science University
Portland, Oregon, United States, 97239
Actively Recruiting
8
Brown University
Providence, Rhode Island, United States, 02912
Actively Recruiting
9
University of Texas Health Science Center
Houston, Texas, United States, 77030
Not Yet Recruiting
10
University of Texas
San Antonio, Texas, United States, 78249
Not Yet Recruiting
11
University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
12
University of Washington
Seattle, Washington, United States, 98195
Actively Recruiting
Research Team
C
Cadasil Consortium
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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