Actively Recruiting
Genotype, Clinical Features and Imaging of Neuroradiological Abnormalities in CADASIL
Led by Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Updated on 2025-04-22
100
Participants Needed
2
Research Sites
205 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The project aims to retrospectively and prospectively analyze a population of CADASIL patients in order to study the natural history of the disease by correlating the symptom spectrum with genetic risk and specific neuroradiological and biological markers \- Stratifying patients according to their disease risk, this could contribute to the discovery of personalized therapeutic targets.
CONDITIONS
Official Title
Genotype, Clinical Features and Imaging of Neuroradiological Abnormalities in CADASIL
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients of either sex older than 18 years of age
- Presence of a pathogenic mutation on genetic analysis of NOTCH3
- If no clear mutation, presence of characteristic deposits (GOM) within small vessels at skin biopsy
You will not qualify if you...
- Do not meet the diagnostic criteria of CADASIL
- Unable to give consent due to aphasic or cognitive impairment
- Deceased at enrollment and next of kin refuse consent for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Italy
Actively Recruiting
2
Hospital Universitario de la Princesa, Madrid
Madrid, Spain
Not Yet Recruiting
Research Team
A
Anna Bersano, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here