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Study of Stellate Ganglion Block Effects on Heart Electrical Activity in Adults with Ventricular Tachycardia Undergoing Catheter Ablation
Led by University of Pennsylvania · Updated on 2025-11-21
20
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
This research aims to evaluate the electrophysiologic and biochemical effects of stellate ganglion block in patients with ventricular tachycardia. It is an early phase 1 interventional trial conducted by the University of Pennsylvania to better understand the impact of autonomic neuromodulation on cardiac function during ventricular tachycardia treatment. Participants will all receive a left-sided percutaneous stellate ganglion block during their planned catheter-based ventricular tachycardia ablation procedure. This treatment is being studied to observe changes in heart electrical properties following the block. During the study, researchers will measure the ventricular effective refractory period, ventricular arrhythmia inducibility, and levels of neuropeptide Y 30 minutes after the stellate ganglion block. These assessments will help reveal the effects of the intervention on heart rhythm and biochemical markers in the short term after the procedure.
CONDITIONS
Brief Title
Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation
Research Team
T
Timothy Markman, MD
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