Actively Recruiting
Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation
Led by University of Pennsylvania · Updated on 2025-11-21
20
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the electrophysiologic and biochemical effects of stellate ganglion block in patients with ventricular tachycardia. It is an early phase 1 interventional trial conducted by the University of Pennsylvania to better understand the impact of autonomic neuromodulation on cardiac function during ventricular tachycardia treatment. Participants will all receive a left-sided percutaneous stellate ganglion block during their planned catheter-based ventricular tachycardia ablation procedure. This treatment is being studied to observe changes in heart electrical properties following the block. During the study, researchers will measure the ventricular effective refractory period, ventricular arrhythmia inducibility, and levels of neuropeptide Y 30 minutes after the stellate ganglion block. These assessments will help reveal the effects of the intervention on heart rhythm and biochemical markers in the short term after the procedure.
CONDITIONS
Brief Title
Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Planned catheter based VT ablation
- Age at least 18 years
You will not qualify if you...
- Pregnancy
- Contraindication to SGB or VT ablation
- Hypersensitivity of local anesthetic of amide type
- Hemodynamic instability during the procedure prior to the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Duration of the ablation procedure
Participants undergo a left sided percutaneous stellate ganglion block during their ventricular tachycardia ablation procedure.
1 procedure visit (in-person)
Trial Site Locations
Total: 1 location
1
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
T
Timothy Markman, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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