Study of Sleep Problems, Fatigue, and Thinking Abilities in Adults with Multiple Sclerosis

What this Trial Is About

Fatigue is a common and impactful symptom in people with multiple sclerosis MS, often linked to sleep disturbances that are frequently overlooked and untreated. This research investigates how sleep disorders affect fatigue and cognitive performance in MS patients, including comparisons across different MS subtypes and the influence of various immunotherapies. The study also explores the use of artificial intelligence AI to enhance the analysis of sleep data. The study is a non-invasive, observational trial involving MS patients with fatigue and a control group of individuals with sleep complaints but no MS. Participants will undergo comprehensive assessments including overnight polysomnography to measure sleep quality, neuropsychological tests, and various questionnaires on fatigue, sleepiness, and mental health. A sub-study will compare patients on different MS therapies. Retrospective sleep data will be used to train AI models for automated sleep analysis. Participants will be involved in baseline evaluations including clinical exams, cognitive testing, and two nights of polysomnography, followed by a telephone assessment about 11 months later. Those with persistent fatigue will return for a repeat of the assessments approximately 12 months after baseline. Researchers will measure fatigue severity, cognitive function, sleep disorders, and other health parameters over time to better understand the relationships among sleep disturbances, fatigue, and cognition in MS.

Cognitive Performance, Sleep Disturbances and Fatigue in Multiple Sclerosis