A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers.
C C Apfel, E Läärä, M Koivuranta...
https://pubmed.ncbi.nlm.nih.gov/10485781Actively Recruiting
Phase Not Applicable
Age: 18Years - 65Years
All Genders
ID06981754
Intravenous Dexamethasone Palmitate for Prophylaxis of Postoperative Nausea and Vomiting After Minimally Invasive Endoscopic Surgery
Led by Beijing Tiantan Hospital · Updated on 2025-11-18
588
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects and safety of dexamethasone palmitate compared to dexamethasone for preventing postoperative nausea and vomiting (PONV) in patients undergoing minimally invasive endoscopic surgeries. Although dexamethasone is commonly used to prevent PONV, some patients still experience symptoms after surgery. Dexamethasone palmitate has a longer-lasting anti-inflammatory effect with potentially fewer side effects, making it important to study its impact in this setting. Participants will be randomly assigned to receive either an intravenous injection of dexamethasone palmitate or dexamethasone after anesthesia induction and before the surgical incision. The dexamethasone palmitate group receives 8 mg (containing 5 mg dexamethasone), while the dexamethasone group receives 5 mg. This treatment is given just before surgery to assess its role in preventing PONV. During the study, participants will be monitored for the incidence of PONV within the first 24 hours after surgery, as well as at multiple time points up to 72 hours postoperatively. Researchers will also assess nausea and vomiting episodes, severity of symptoms, rescue antiemetic use, participant satisfaction, recovery quality, pain levels using the VAS scale, length of postoperative hospital stay, and safety outcomes throughout the research period. The total participation duration includes assessments at discharge and up to one month after surgery.
CONDITIONS
Brief Title
Dexamethasone Palmitate for PONV After Minimally Invasive Endoscopic Surgery
Who Can Participate
Age: 18Years - 65Years
All Genders
Eligibility Criteria
You may qualify if you...
- Aged 18 to 65 years
- Providing written informed consent
- Scheduled for elective minimally invasive endoscopic surgery (laparoscopic or thoracoscopic) under general anesthesia
You will not qualify if you...
- Known allergy to dexamethasone
- Use of any systemic glucocorticoids within 3 months before trial entry
- History of severe heart disease, liver or kidney failure, or systemic rheumatic diseases
- Cognitive impairment or severe mental illness
- Uncontrolled diabetes or infectious diseases
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Single administration on the day of surgery
Participants receive an intravenous injection of either dexamethasone palmitate or dexamethasone after anesthesia induction and before surgical incision to prevent postoperative nausea and vomiting.
1 treatment visit (in-person)
Postoperative Follow-up
Duration - Up to 1 month postoperatively
Participants are monitored for postoperative nausea and vomiting, recovery quality, and safety outcomes.
Multiple visits at 6 hours, 24 hours, 48 hours, 72 hours, discharge, and 1 month postoperatively
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
Loading map...
Research Team
F
Fang Luo
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting.
Tong J Gan, Kumar G Belani, Sergio Bergese...
https://pubmed.ncbi.nlm.nih.gov/32467512Risk factors for postoperative nausea and vomiting.
Tong J Gan
https://pubmed.ncbi.nlm.nih.gov/16717343Consensus guidelines for the management of postoperative nausea and vomiting.
Tong J Gan, Pierre Diemunsch, Ashraf S Habib...
https://pubmed.ncbi.nlm.nih.gov/24356162Comparison of the prophylactic anti-emetic efficacy of ramosetron and ondansetron in patients at high-risk for postoperative nausea and vomiting after total knee replacement.
T S Hahm, Justin Sangwook Ko, S J Choi...
https://pubmed.ncbi.nlm.nih.gov/20337618Postoperative nausea and vomiting following inpatient surgeries in a teaching hospital: a retrospective database analysis.
Ashraf S Habib, Ya-Ting Chen, Akiko Taguchi...
https://pubmed.ncbi.nlm.nih.gov/16846542Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial).
DREAMS Trial Collaborators and West Midlands Research Collaborative
https://pubmed.ncbi.nlm.nih.gov/28420629Randomized clinical trial of the effect of preoperative dexamethasone on nausea and vomiting after laparoscopic cholecystectomy.
C V Feo, D Sortini, R Ragazzi...
https://pubmed.ncbi.nlm.nih.gov/16400707Prolonged Duration Local Anesthesia Using Liposomal Bupivacaine Combined With Liposomal Dexamethasone and Dexmedetomidine.
Alina Y Rwei, Robert T Sherburne, David Zurakowski...
https://pubmed.ncbi.nlm.nih.gov/29239940INDEX study: intravenous dexamethasone palmitate for prophylaxis of postoperative nausea and vomiting: a study protocol for a randomised controlled study.
Hao Ren, Chunmei Zhao, Linsong Yuan...
https://pubmed.ncbi.nlm.nih.gov/41320217