Comparing Intravenous Dexmedetomidine and Lignocaine to Reduce Heart and Blood Pressure Changes During Intubation in Cardiac Surgery Patients

What this Trial Is About

This research aims to compare the effects of two medications, intravenous dexmedetomidine and lignocaine, on heart and blood pressure responses during laryngoscopy and endotracheal intubation in patients undergoing cardiac surgery. The study focuses on patients with a higher risk of cardiovascular events and seeks to understand how these drugs influence hemodynamic responses during the procedure. Participants will be randomly assigned to receive either 0.5 mcgkg of dexmedetomidine given 10 minutes before laryngoscopy or 1.5 mgkg of lignocaine administered 3 minutes before laryngoscopy. The medications are given through a vein before placing the breathing tube, and the process is managed in a way to maintain confidentiality and random assignment. Throughout the study, blood pressure and heart rate will be measured before the procedure and at 1, 3, 5, and 10 minutes after intubation. Researchers will collect demographic information and monitor vital signs using arterial catheters and pulse oximeters. The main outcomes measured are mean arterial pressure and heart rate changes during and after intubation. Participants safety and data confidentiality are maintained throughout the trial.

Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial