Actively Recruiting
Comparison of Intravenous Dexmedetomidine and Lignocaine in Reducing Hemodynamic Responses During Laryngoscopy and Endotracheal Intubation in Patients Undergoing Cardiac Surgery
Led by Rawalpindi Institute of Cardiology · Updated on 2026-05-28
70
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare the effects of two medications, intravenous dexmedetomidine and lignocaine, on heart and blood pressure responses during laryngoscopy and endotracheal intubation in patients undergoing cardiac surgery. The study focuses on patients with a higher risk of cardiovascular events and seeks to understand how these drugs influence hemodynamic responses during the procedure. Participants will be randomly assigned to receive either 0.5 mcg/kg of dexmedetomidine given 10 minutes before laryngoscopy or 1.5 mg/kg of lignocaine administered 3 minutes before laryngoscopy. The medications are given through a vein before placing the breathing tube, and the process is managed in a way to maintain confidentiality and random assignment. Throughout the study, blood pressure and heart rate will be measured before the procedure and at 1, 3, 5, and 10 minutes after intubation. Researchers will collect demographic information and monitor vital signs using arterial catheters and pulse oximeters. The main outcomes measured are mean arterial pressure and heart rate changes during and after intubation. Participants' safety and data confidentiality are maintained throughout the trial.
CONDITIONS
Brief Title
Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years
- American Society of Anesthesiologists (ASA) physical status III or IV
- Patients at risk of cardiovascular events
You will not qualify if you...
- Known allergy to dexmedetomidine or lignocaine
- Use of medications that interfere with the study, such as beta-blockers or calcium channel blockers
- Pregnant or breastfeeding women
- History of airway anomalies or difficult intubation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Single day on the day of surgery
Participants receive an intravenous study medication before laryngoscopy and endotracheal intubation to reduce hemodynamic responses during cardiac surgery.
1 visit (in-person) on the surgery day
Trial Site Locations
Total: 1 location
1
Rawalpindi Institute of Cardiology
Rawalpindi, Punjab Province, Pakistan, 46000
Actively Recruiting
Research Team
N
Namrah Zujaj, MBBS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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