Actively Recruiting
Early Neurovascular Adaptations in Aging Women
Led by University of Missouri-Columbia · Updated on 2025-11-26
64
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
U
University of Missouri-Columbia
Lead Sponsor
A
American Heart Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying early changes in blood vessel function and the sympathetic nervous system in women as they age. This early phase 1 trial is focused on understanding how these adaptations occur in women between 18 and 70 years old. The study aims to provide insights into vascular health and nervous system function related to aging in females. Participants will receive several drugs infused directly into an artery to observe their effects on blood flow. These drugs include norepinephrine, isoproterenol, acetylcholine, nitroprusside, and estrogen. Each drug is given in increasing doses to assess how the blood vessels respond during the study. During the trial, researchers will measure changes in forearm blood flow from baseline while the drugs are infused. Participants will be monitored for safety and responses to these infusions. The study includes women assigned female at birth, and participation may last as long as the treatment and assessments require. The study also allows healthy volunteers to join and includes detailed monitoring of vascular responses.
CONDITIONS
Brief Title
Early Neurovascular Adaptations in Aging Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Assigned female at birth (AFAB)
- Between 18 and 70 years of age
You will not qualify if you...
- Assigned male at birth (AMAB)
- Pregnancy or breastfeeding
- Body mass index 30 kg/m2 or higher
- Taking medications that affect metabolic, autonomic, or respiratory function
- Use of oral hormonal contraception in the last 6 months
- History of hormone replacement therapy
- History of hysterectomy or oophorectomy
- Current smoking or nicotine use
- Increased risk of bleeding, pro-coagulant or clotting disorders, or on anticoagulation therapy
- Chronic disease
- Blood pressure 140/90 mmHg or higher
- Communication barriers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single session
Participants receive intra-arterial infusions of different drugs in a dose-response fashion to study neurovascular adaptations.
1 treatment visit (in-person)
Trial Site Locations
Total: 1 location
1
University of Missouri-Columbia
Columbia, Missouri, United States, 65211
Actively Recruiting
Research Team
J
Jacqueline K Limberg
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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