Study of Early Neurovascular Changes in Women Ages 18 to 70 Focusing on the Sympathetic Nervous System and Blood Flow

What this Trial Is About

Researchers are studying early changes in blood vessel function and the sympathetic nervous system in women as they age. This early phase 1 trial is focused on understanding how these adaptations occur in women between 18 and 70 years old. The study aims to provide insights into vascular health and nervous system function related to aging in females. Participants will receive several drugs infused directly into an artery to observe their effects on blood flow. These drugs include norepinephrine, isoproterenol, acetylcholine, nitroprusside, and estrogen. Each drug is given in increasing doses to assess how the blood vessels respond during the study. During the trial, researchers will measure changes in forearm blood flow from baseline while the drugs are infused. Participants will be monitored for safety and responses to these infusions. The study includes women assigned female at birth, and participation may last as long as the treatment and assessments require. The study also allows healthy volunteers to join and includes detailed monitoring of vascular responses.

Early Neurovascular Adaptations in Aging Women