Long-term Study of Brain Amyloid Changes and Cognitive Aging in Adults 55 and Older Using PET Imaging

What this Trial Is About

Researchers are studying the effects of amyloids, protein groups that accumulate in the brain with age, on brain structure and function in adults aged 55 years and older. This research is part of the Baltimore Longitudinal Study of Aging and aims to understand how changes in amyloid levels relate to cognitive decline, memory problems, and conditions such as Alzheimers disease. The study also explores factors like sex differences, genetic risks, and hormone effects on brain aging. Participants will undergo positron emission tomography PET and computed tomography CT scans to visualize amyloid distribution in the brain. A tracer is injected into the bloodstream to highlight amyloids during imaging. Scans occur every 1 to 4 years depending on the participants age those 80 and older are scanned yearly. Cognitive tests assessing memory, mental skills, mood, and daily activities are also conducted either in person or by phone. Some participants are part of an autopsy program comparing imaging and post-mortem findings. During the 5-year study, participants attend scheduled visits for imaging and cognitive assessments. They provide contact information for a person familiar with their daily routine who may also be interviewed. Researchers measure amyloid accumulation over time along with brain structure and cognitive changes. The study monitors health and cognitive status regularly to understand aging and identify factors influencing resilience against memory impairment.

Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging