Actively Recruiting
Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial
Led by TC Erciyes University · Updated on 2026-05-20
100
Participants Needed
1
Research Sites
5 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This clinical trial investigates the link between various root canal irrigation techniques and the pain experienced after root canal treatment, specifically focusing on single-visit endodontic retreatment for patients with apical periodontitis. The study is designed as a prospective randomized clinical trial led by TC Erciyes University, aiming to compare the effects of different irrigation protocols and activation methods on postoperative pain. Participants will be randomly assigned to one of four experimental groups combining different irrigation solutions and activation techniques: NaOCl/EDTA with either Conventional Needle Irrigation (CNI) or Passive Ultrasonic Activation (PUA), and NaOCl/Dual Rinse HEDP with either CNI or PUA. These methods are evaluated for their impact on pain after the procedure. The trial includes a single treatment visit and follows participants for 3 to 5 months to assess outcomes. During the study, participants will complete surveys to evaluate postoperative pain following the root canal retreatment. The research team will monitor and analyze pain levels related to the irrigation techniques. The total participation duration spans several months, with assessments conducted during this period to understand the relationship between treatment methods and patient pain experience.
CONDITIONS
Brief Title
Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18-60 years who are medically healthy (ASA I or II)
- Mature, single-rooted and canal teeth with root canal treatment done at least four years ago
- Teeth with previous root canal filling 2-4 mm short of the apex
- Teeth without need for periodontal or prosthetic treatment and periapical index score between 2 and 4
- Teeth diagnosed with asymptomatic apical periodontitis having single root and canal
- Teeth suitable for rubber dam isolation
You will not qualify if you...
- Patients who took analgesics, antibiotics, or corticosteroids within two weeks before retreatment
- Teeth with periodontal attachment loss
- Teeth with vertical root fractures, external root resorption, or perforations
- Teeth with retained broken instruments
- Non-restorable teeth
- Pregnant or breastfeeding patients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Single visit
Participants receive one of two different root canal irrigation protocols and activation techniques during a single-visit endodontic retreatment.
1 visit (in-person)
Duration - 3 to 5 months
Participants complete surveys to evaluate postoperative pain after the root canal treatment.
Periodic surveys during follow-up
Trial Site Locations
Total: 1 location
1
Erciyes University
Kayseri, Turkey (Türkiye)
Actively Recruiting
Research Team
İ
İPEK E ERASLAN AKYÜZ
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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