Study of Gastric Bypass and Sleeve Gastrectomy Surgeries on How the Body Controls Glucose and Insulin After Eating

What this Trial Is About

Researchers are studying the effects of two types of bariatric surgeries, gastric bypass and sleeve gastrectomy, on how the body controls glucose metabolism. The study focuses on the hormonal and neural factors that affect islet cell response after eating, aiming to understand differences between these surgeries independent of weight loss. This research could help develop new treatments for diabetes and improve blood sugar control in patients who have partial or relapsed diabetes after surgery. Participants will receive one of two drug interventions Exendin-9-39 to study the role of GLP-1 on glucose metabolism and insulin secretion after glucose and protein intake, or Atropine to assess how neural activation influences insulin secretion and glucose metabolism. The study is randomized and single-blind, with procedures lasting up to seven hours, during which insulin levels are measured at specific intervals after nutrient ingestion. During the study, participants will undergo detailed monitoring of insulin levels and other metabolic assessments following meal ingestion. The research team will collect data for up to seven hours per session, focusing on changes in glucose metabolism. Participants must be able to visit the clinical research center for these assessments. The study runs until August 2027 and includes adults aged 18 to 65 years.

The Effects of Bariatric Surgeries on Glucose Metabolism