Actively Recruiting
Randomized Controlled Crossover Trial on the Effects of Daytime, Nighttime, and Combined Heat Exposure on Human Health
Led by Jian Cheng · Updated on 2026-03-30
35
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the short-term effects of high-temperature exposure during both day and night on various bodily functions including cardiovascular, respiratory, neurocognitive, and metabolic health. This randomized controlled crossover trial involves about 50 healthy young adults in Hefei, China, aiming to understand how heat affects these systems and to explore the biological mechanisms behind these effects. Participants will experience three different heat exposure conditions in random order: nighttime heat at 306C, daytime heat at 326C, and combined day-night heat exposure. Each exposure lasts about 8 hours during typical sleep or work periods, with breaks of at least three days between sessions to avoid carryover effects. Control exposures at a neutral temperature of 266C will also occur for comparison. During exposures, participants will rest to limit physical activity. Throughout the study, health assessments will be made before, during, and after each exposure. These include heart rate monitoring with a smart band for 24 hours, blood pressure, lung function tests, cognitive and psychological evaluations, and collection of blood and urine samples to measure inflammation, oxidative stress, and kidney function markers. Mood and stress levels will also be assessed to provide a comprehensive picture of the acute physiological and psychological responses to heat exposure.
CONDITIONS
Brief Title
The Effects of Daytime, Nighttime, and Combined Heat Exposure on Human Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 30 years
- In good health with no history of cardiovascular, respiratory, diabetes, endocrine, neurological, or psychiatric conditions
- No smoking, alcohol addiction, or substance abuse history
- No prior sensitivity to high-temperature environments
You will not qualify if you...
- Fever, colds, infectious diseases, or significant physical trauma within two weeks before testing
- Use of medications affecting psychological, cognitive, cardiovascular, or respiratory functions
- Pregnant or lactating females
- Participation scheduled during menstruation
- History of fainting or severe discomfort caused by high temperatures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Multiple 8-hour exposure sessions with at least 3 days washout between sessions
Participants undergo randomized crossover exposures to daytime heat, nighttime heat, and combined day-night heat in controlled temperature chambers while resting. Each exposure session lasts about 8 hours with a washout period of at least 3 days between sessions. Health assessments including heart monitoring, blood pressure, lung function, cognitive tests, psychological questionnaires, and biological sample collection are conducted before, during, and after each exposure.
Several visits corresponding to each exposure session and assessments
Trial Site Locations
Total: 1 location
1
Anhui Medical University
Hefei, Anhui, China, 230032
Actively Recruiting
Research Team
J
Jian Jian Cheng
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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