Actively Recruiting

Phase 3
Age: 18Years - 99Years
All Genders
NCT07311850

Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

Led by Metsera, a wholly owned subsidiary of Pfizer · Updated on 2026-04-21

3500

Participants Needed

196

Research Sites

122 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks. The primary endpoint will be assessed after 64 weeks of treatment with the secondary at 84 weeks.

CONDITIONS

Official Title

Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

Who Can Participate

Age: 18Years - 99Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults with a body mass index (BMI) of 30 kg/m2 or higher
  • Adults with BMI between 27.0 and less than 30.0 kg/m2 who have at least one weight-related health condition such as hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease
Not Eligible

You will not qualify if you...

  • Any form of diabetes
  • Significant weight change over 5 kg (11 pounds) within 3 months before screening
  • Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
  • History of chronic pancreatitis or acute pancreatitis within 180 days before screening
  • Active or symptomatic gallbladder disease

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 196 locations

1

Headlands Research

Scottsdale, Arizona, United States, 85260

Actively Recruiting

2

Alliance Research Institute

Canoga Park, California, United States, 91304

Actively Recruiting

3

Clinical Innovations, Inc dba CITrials

Riverside, California, United States, 92506

Actively Recruiting

4

Peninsula Headlands LLC

Rolling Hills, California, United States, 90274

Actively Recruiting

5

Collaborative Neuroscience Research, LLC

Torrance, California, United States, 90504

Actively Recruiting

6

CenExcel Rocky Mountain Clinical Research, LLC

Englewood, Colorado, United States, 80113

Actively Recruiting

7

Research Centers of America

Hollywood, Florida, United States, 33024

Actively Recruiting

8

Future Medical Research (Civia Health)

Longwood, Florida, United States, 32750

Actively Recruiting

9

Advanced Clinical Research

Miami, Florida, United States, 33156

Actively Recruiting

10

Oviedo Medical Research

Oviedo, Florida, United States, 32765

Actively Recruiting

11

CenExel FCR - ForCare Clinical Research

Tampa, Florida, United States, 33613

Actively Recruiting

12

DelRicht Research @ Springer Wellness and Restorative Health

Atlanta, Georgia, United States, 30329

Actively Recruiting

13

CenExel iResearch, LLC

Savannah, Georgia, United States, 31405

Actively Recruiting

14

CenExel CBH Health

Gaithersburg, Maryland, United States, 20877

Actively Recruiting

15

Civia Health Shelby

Shelby, Michigan, United States, 48315

Not Yet Recruiting

16

Clinical Research Professionals

Chesterfield, Missouri, United States, 63005

Actively Recruiting

17

Civia Health St. Louis

Creve Coeur, Missouri, United States, 63141

Not Yet Recruiting

18

Civia Health Independence

Independence, Missouri, United States, 64055

Not Yet Recruiting

19

Quality Clinical Research Inc

Omaha, Nebraska, United States, 68114

Actively Recruiting

20

Primary Care Research (Civia Health)

Papillion, Nebraska, United States, 68046

Actively Recruiting

21

CenExel HRI - Hassman Research Institute

Marlton, New Jersey, United States, 08053

Actively Recruiting

22

Forum Health Cary

Cary, North Carolina, United States, 27511

Actively Recruiting

23

Eximia EquiHealth Research

Durham, North Carolina, United States, 27704

Actively Recruiting

24

TMA Headlands LLC

Wilmington, North Carolina, United States, 28403

Actively Recruiting

25

Summit Headlands LLC

Portland, Oregon, United States, 97210

Actively Recruiting

26

Tribe Clinical Research, LLC

Greenville, South Carolina, United States, 29607

Actively Recruiting

27

Tribe Clinical Research, LLC

Spartanburg, South Carolina, United States, 29301

Actively Recruiting

28

Civia Health Goodlettsville

Goodlettsville, Tennessee, United States, 37072

Actively Recruiting

29

Civia Health Nashville

La Vergne, Tennessee, United States, 37086

Actively Recruiting

30

Civia Health Memphis

Memphis, Tennessee, United States, 38117

Not Yet Recruiting

31

Forum Austin (Civia Health)

Austin, Texas, United States, 78578

Actively Recruiting

32

Cedar Health Research

Dallas, Texas, United States, 75251

Not Yet Recruiting

33

GLRI El Paso Research

El Paso, Texas, United States, 79936

Actively Recruiting

34

Dallas Clinical Research Center (Pillar Clinical Research)

Richardson, Texas, United States, 75080

Actively Recruiting

35

Pantheon Clinical Research

Bountiful, Utah, United States, 84010

Actively Recruiting

36

CINME

Buenos Aires, Argentina, C1056ABI

Not Yet Recruiting

37

CEDIC

Buenos Aires, Argentina, C1060

Not Yet Recruiting

38

Centro Medico Viamonte

Buenos Aires, Argentina, C1120AAC

Not Yet Recruiting

39

Clinica Privada Velez Sarsfield

Córdoba, Argentina, 5000

Not Yet Recruiting

40

Instituto de Investigaciones Clinicas Cordoba

Córdoba, Argentina, X5000AAW

Not Yet Recruiting

41

CIDIM

Córdoba, Argentina, X5000AVE

Not Yet Recruiting

42

CIPADI - Centro Integral de Prevencion Y Atencion en Diabetes

Godoy Cruz, Argentina, M5501ARP

Not Yet Recruiting

43

IIC Mar del Plata

Mar del Plata, Argentina, 7600

Not Yet Recruiting

44

CIAD Moron

Morón, Argentina, B1708EPE

Not Yet Recruiting

45

Centro Medico Privado de Reumatologia

San Miguel de Tucumán, Argentina, T4000AXA

Not Yet Recruiting

46

Instituto Medico Catamarca (IMEC)

Santa Fe, Argentina, S2000

Not Yet Recruiting

47

MHAT Botevgrad

Botevgrad, Bulgaria, 2140

Not Yet Recruiting

48

4 Life EOOD

Burgas, Bulgaria, 8018

Not Yet Recruiting

49

Multiprofile Hospital for Active Treatment Dobrich AD (MHAT Dobrich AD)

Dobrich, Bulgaria, 9300

Not Yet Recruiting

50

Medical Center New Polyclinic Gabrovo Ltd.

Gabrovo, Bulgaria, 5300

Not Yet Recruiting

51

Medical Center Zdrave 1

Kozloduy, Bulgaria, 3320

Not Yet Recruiting

52

FutureMeds Plovdiv

Plovdiv, Bulgaria, 4000

Not Yet Recruiting

53

MHAT Sveta Karidad EAD

Plovdiv, Bulgaria, 4004

Not Yet Recruiting

54

Diagnostic Consultative Center Aleksandrovska

Sofia, Bulgaria, 1431

Not Yet Recruiting

55

Medical Center Hera EOOD

Sofia, Bulgaria, 1710

Not Yet Recruiting

56

Prevencia - 2000 - Medical Center for Prehospital Medical Care OOD

Stara Zagora, Bulgaria, 6000

Not Yet Recruiting

57

UMHAT "Prof. Dr. Stoyan Kirkovich"AD

Stara Zagora, Bulgaria, 6003

Not Yet Recruiting

58

MC Nova Clinic

Varna, Bulgaria, 9000

Not Yet Recruiting

59

Medical Centre Pratia Clinic EOOD

Varna, Bulgaria, 9020

Not Yet Recruiting

60

Medical Center - Clinic Nova

Varna, Bulgaria

Not Yet Recruiting

61

MC Nevromedics Ltd.

Veliko Tarnovo, Bulgaria, 5005

Not Yet Recruiting

62

Medical Center Berbatov

Yambol, Bulgaria, 8600

Not Yet Recruiting

63

C-health Research

Edmonton, Alberta, Canada, T6H 2L4

Not Yet Recruiting

64

Synergy Medical Clinic

Sherwood Park, Alberta, Canada, T8H 0N2

Not Yet Recruiting

65

Centricity Research Etobicoke Endocrinology

Etobicoke, Ontario, Canada, M9R 4E1

Not Yet Recruiting

66

The Wharton Medical Clinic Clinical Trials Inc

Hamilton, Ontario, Canada, L8L 5G8

Not Yet Recruiting

67

LMC Diabetes & Endocrinology - Bayview (Centricity Research Toronto LMC Multispecialty)

Toronto, Ontario, Canada, M4G 3E8

Not Yet Recruiting

68

Manna Research Mirabel

Mirabel, Quebec, Canada, J7J 2K8

Not Yet Recruiting

69

Pratia Brno,s.r.o

Brno, Czechia, 60200

Not Yet Recruiting

70

Nemocnice Jihlava

Jihlava, Czechia, 58601

Not Yet Recruiting

71

Edumed s.r.o.

Náchod, Czechia, 54701

Not Yet Recruiting

72

Agentura science pro s.r.o.

Olomouc, Czechia, 77900

Not Yet Recruiting

73

PreventaMed s.r.o.

Olomouc, Czechia, 77900

Not Yet Recruiting

74

CCR Ostrava

Ostrava, Czechia, 702 00

Not Yet Recruiting

75

Pratia Pardubice

Pardubice, Czechia, 53002

Not Yet Recruiting

76

Fakultní nemocnice Královské Vinohrady

Prague, Czechia, 100 34

Not Yet Recruiting

77

Synexus/Trialmed Prague

Prague, Czechia, 120 00

Not Yet Recruiting

78

ResTrial s.r.o.

Prague, Czechia, 18100

Not Yet Recruiting

79

CDG Studienambulanz Hartard

Munich, Bavaria, Germany, 80809

Not Yet Recruiting

80

Studienzentrum FMZ Radowsky

Leipzig, Saxony, Germany, 4179

Not Yet Recruiting

81

Kardiologische Praxis Dr. med. univ. Wolfgang Jungmair

Bad Homburg, Germany, 61348

Not Yet Recruiting

82

Klinische Forschung Berlin-Mitte GmbH

Berlin, Germany, 10117

Not Yet Recruiting

83

FutureMeds Berlin

Berlin, Germany, 10629

Not Yet Recruiting

84

Velocity Clinical Research Germany, Berlin

Berlin, Germany, 12205

Not Yet Recruiting

85

Diabetespraxis Dr. Braun

Berlin, Germany, 13187

Not Yet Recruiting

86

Pratia

Dresden, Germany, 1069

Not Yet Recruiting

87

Medizentrum Essen Borbeck

Essen, Germany, 45355

Not Yet Recruiting

88

Praxis am Markt - Dr. Bernd Becker

Essen, Germany, 45355

Not Yet Recruiting

89

Klinische Forschung Hamburg GmbH / Pratia

Hamburg, Germany, 20253

Not Yet Recruiting

90

Diabetes Studienzentrum Wilhelmsburg

Hamburg, Germany, 21109

Not Yet Recruiting

91

DZHW

Hamburg, Germany, 22607

Not Yet Recruiting

92

Praxis Reinfeld Mitte

Holstein, Germany, 23858

Not Yet Recruiting

93

Zentrum fuer klinische Forschung Koeln Duennwald

Kaln, Germany, 51069

Not Yet Recruiting

94

Klinische Forschung Karlsruhe GmbH

Karlsruhe, Germany, 76137

Not Yet Recruiting

95

AmBeNet GmbH

Leipzig, Germany, 4107

Not Yet Recruiting

96

IDFM GmbH

Münster, Germany, 48145

Not Yet Recruiting

97

Gemeinschaftspraxis PD Dr. med. habil. Holger Kittner & Dr. Hartig

Naunhof, Germany, 4683

Not Yet Recruiting

98

FutureMeds Frankfurt/Offenbach

Offenbach, Germany, 63065

Not Yet Recruiting

99

Zentrum für kliniche Studien Allgäu-Oberschwaben

Wangen, Germany, 88239

Not Yet Recruiting

100

Medislim GmbH

Weinheim, Germany, 69469

Not Yet Recruiting

101

Zdrowie Osteo Medic sc L i A Racewicz, A i J Supronik

Bialystok, Poland, 15-351

Not Yet Recruiting

102

NZOZ Centrum Medyczne KERmed

Bydgoszcz, Poland, 85-231

Not Yet Recruiting

103

Centrum medyczne Pratia Bydgoszcz

Bydgoszcz, Poland, 85-796

Not Yet Recruiting

104

Pratia Chojnice

Chojnice, Poland, 89-600

Not Yet Recruiting

105

Synexus Polska Sp. z o.o., Oddzial w Czestochowie

Częstochowa, Poland, 42-202

Not Yet Recruiting

106

Synexus Polska Sp z o.o.

Gdansk, Poland, 80-382

Not Yet Recruiting

107

Centrum Badan Klinicznych PI-House Sp. z o.o.

Gdansk, Poland, 80-546

Not Yet Recruiting

108

Centrum Medyczne Pratia Gdynia

Gdynia, Poland, 81-338

Not Yet Recruiting

109

FutureMeds Gdynia

Gdynia, Poland, 81-384

Not Yet Recruiting

110

Synexus Polska Sp. z o.o. Oddzial w Gdyni

Gdynia, Poland, 81-537

Not Yet Recruiting

111

Synexus Polska Sp. Z O.O. Oddzial W Katowicach

Katowice, Poland, 40-040

Not Yet Recruiting

112

Centrum Medyczne Pratia Katowice

Katowice, Poland, 40-081

Not Yet Recruiting

113

FutureMeds Krakow

Krakow, Poland, 31-501

Not Yet Recruiting

114

Synexus Polska Sp. z o.o., Oddzial w Lodzi

Lodz, Poland, 90-127

Not Yet Recruiting

115

Santa Sp. z.o.o.

Lodz, Poland, 90-302

Not Yet Recruiting

116

Centrum Terapii Współczesnej J.M. Jasnorzewska Spółka Komandytowo-Akcyjna

Lodz, Poland, 90-338

Not Yet Recruiting

117

FutureMeds Lodz

Lodz, Poland, 91-393

Not Yet Recruiting

118

Ekamed Sp. z o. o.

Lublin, Poland, 20-718

Not Yet Recruiting

119

FutureMeds Olsztyn

Olsztyn, Poland, 10-165

Not Yet Recruiting

120

Medicome Sp. z o.o. Oświęcimskie Centrum Badań Klinicznych

Oświęcim, Poland, 32-600

Not Yet Recruiting

121

IRMED

Piotrkow Trybunalski, Poland, 97-300

Not Yet Recruiting

122

Trialmed CRS

Piotrkow Trybunalski, Poland, 97-300

Not Yet Recruiting

123

Synexus Polska Sp. z o.o., Oddział w Poznaniu

Poznan, Poland, 60-702

Not Yet Recruiting

124

Praktyka Lekarska Ewa Krzyzagorska

Poznan, Poland, 61-655

Not Yet Recruiting

125

ETG Siedlce

Siedlce, Poland, 08-110

Not Yet Recruiting

126

Metabolica Sp. z o.o., NZOZ METABOLICA Ośrodek Badań Klinicznych

Tarnów, Poland, 33-100

Not Yet Recruiting

127

FutureMeds Warszawa Centrum

Warsaw, Poland, 00-215

Not Yet Recruiting

128

Instytut Diabetologii.sp.z.o.o.

Warsaw, Poland, 02-117

Not Yet Recruiting

129

Synexus Polska Sp. z o.o., Oddzial w Warszawie

Warsaw, Poland, 02-672

Not Yet Recruiting

130

Etg Warszawa

Warsaw, Poland, 02-677

Not Yet Recruiting

131

FutureMeds Warszawa Targowek

Warszawa Targowek, Poland, 03-291

Not Yet Recruiting

132

Synexus Polska Sp. z o.o., Oddział we Wrocławiu

Wroclaw, Poland, 50-381

Not Yet Recruiting

133

FutureMeds Wroclaw

Wroclaw, Poland, 53-673

Not Yet Recruiting

134

Minimed S.R.L.

Bacau, Romania

Not Yet Recruiting

135

Futuremeds S.R.L., Brasov

Brasov, Romania

Not Yet Recruiting

136

Hightech Medical Services S.R.L (Centrul pentru Studiul Metabolismului)

Bucharest, Romania, 011053

Not Yet Recruiting

137

Fundatia Dr Victor Babes

Bucharest, Romania, 30303

Not Yet Recruiting

138

Institutul Clinic Fundeni

Bucharest, Romania

Not Yet Recruiting

139

Institutul National de Endocrinologie "C.I. Parhon"

Bucharest, Romania

Not Yet Recruiting

140

Futuremeds S.R.L., Craiova

Craiova, Romania

Not Yet Recruiting

141

Futuremeds S.R.L., Galati

Galati, Romania

Not Yet Recruiting

142

Centru Medical "GRANDMED"

Oradea, Romania

Not Yet Recruiting

143

Sc Gensan Srl/Policlinica Astra

Sibiu, Romania, 550371

Not Yet Recruiting

144

Centrul Medical Mediab - Mediab Srl

Târgu Mureş, Romania

Not Yet Recruiting

145

Medispektrum

Bratislava, Slovakia, 85101

Not Yet Recruiting

146

DIABEDA s.r.o.

Bratislava, Slovakia, Bratislava

Not Yet Recruiting

147

Poliklinika Váš Lekár

Bratislava - Ružinov, Slovakia, 91109

Not Yet Recruiting

148

Cardio D&R Košice

Košice, Slovakia, 040 22

Not Yet Recruiting

149

Medical group Kosice s.r.o.

Košice, Slovakia, 04001

Not Yet Recruiting

150

MEDI-DIA s.r.o.

Prešov, Slovakia, 080 01

Not Yet Recruiting

151

Tatratrial s.r.o.

Rožňava, Slovakia, 048 01

Not Yet Recruiting

152

JAL s.r.o.

Trnava, Slovakia, 91701

Not Yet Recruiting

153

Medivasa sro

Žilina, Slovakia, 01001

Not Yet Recruiting

154

Hospital Universitario Virgen de la Victoria

Málaga, Málaga, Spain, 29010

Not Yet Recruiting

155

Hospital Universitario Torrecárdenas (CPE Bola Azul)

Almería, Spain, 04009

Not Yet Recruiting

156

Hospital Universitari Vall d'Hebron

Barcelona, Spain, 08035

Not Yet Recruiting

157

Hospital Vithas Sevilla

Castilleja de la Cuesta, Spain, 41950

Not Yet Recruiting

158

Futuremeds Spain Cadiz

Chiclana de la Frontera, Spain, 11139

Not Yet Recruiting

159

Futuremeds Spain Madrid

Madrid, Spain, 28003

Not Yet Recruiting

160

Hospital Universitari Son Espases

Palma de Mallorca, Spain, 07120

Not Yet Recruiting

161

Hospital Virgen del Camino

Sanlúcar de Barrameda, Spain, 11540

Not Yet Recruiting

162

Nuevas Tecnologías en Diabetes y Endocrinología S.L.

Seville, Spain, 41003

Not Yet Recruiting

163

Futuremeds Spain Sevilla

Seville, Spain, 41012

Not Yet Recruiting

164

Ecg Médica S.L.

Valencia, Spain, 46015

Not Yet Recruiting

165

Boots Peterborough

Peterborough, Cambridgeshire, United Kingdom, PE1 1NW

Not Yet Recruiting

166

Bodyline Medical Clinic Warrington

Warrington, Cheshire EAST, United Kingdom, WA1 3TZ

Not Yet Recruiting

167

Civia Health Sunderland

Hendon, CITY of Sunderland, United Kingdom, SR1 1PB

Not Yet Recruiting

168

Boots Brighton

Brighton, EAST Sussex, United Kingdom, BN1 2BE

Not Yet Recruiting

169

Bodyline Medical Clinic St Helens

St Helens, Liverpool, United Kingdom, WA9 1AF

Not Yet Recruiting

170

Bodyline Medical Research Openshaw

Openshaw, Manchester, United Kingdom, M11 1AA

Not Yet Recruiting

171

Boots Nottingham

Nottingham, Nottinghamshire, United Kingdom, NG1 3QS

Not Yet Recruiting

172

FutureMeds Glasgow McCafferty House

Glasgow, Scotland, United Kingdom, G20 7BE

Not Yet Recruiting

173

Synexus/Trialmed Glasgow

Bellshill, United Kingdom, ML4 3NJ

Not Yet Recruiting

174

Synexus/Trialmed Midlands

Birmingham, United Kingdom, B15 2 SQ

Not Yet Recruiting

175

FutureMeds (Birmingham)

Birmingham, United Kingdom, B21 9RY

Not Yet Recruiting

176

Boots Birmingham

Birmingham, United Kingdom, B4 7TA

Not Yet Recruiting

177

Southmead Hospital

Bristol, United Kingdom, BS10 5NB

Not Yet Recruiting

178

FutureMeds Liverpool

Bromborough, United Kingdom, CH62 6EE

Not Yet Recruiting

179

Synexus/Trialmed Cardiff

Cardiff, United Kingdom, CF15 9SS

Not Yet Recruiting

180

Panthera Biopartners Limited - Enfield

Enfield, United Kingdom, EN3 4GS

Not Yet Recruiting

181

Panthera Biopartners Limited - Glasgow

Glasgow, United Kingdom, G51 4TY

Not Yet Recruiting

182

Bodyline Medical Clinic Crosby

Liverpool, United Kingdom, L224QQ

Not Yet Recruiting

183

FutureMeds London

London, United Kingdom, NW10 2PB

Not Yet Recruiting

184

Synexus/Trialmed Manchester

Manchester, United Kingdom, M15 6SE

Not Yet Recruiting

185

Kiltearn Medical Centre

Nantwich, United Kingdom, CW5 5NX

Not Yet Recruiting

186

FutureMeds Newcastle

Newcastle upon Tyne, United Kingdom, NE6 1SG

Not Yet Recruiting

187

DANES Medical Centre

Northampton, United Kingdom, NN1 5PH

Not Yet Recruiting

188

Panthera Biopartners Limited - Preston

Preston, United Kingdom, PR2 9QB

Not Yet Recruiting

189

Panthera Biopartners Limited - Rochdale

Rochdale, United Kingdom, OL11 4AU

Not Yet Recruiting

190

Clifton Medical Centre

Rotherham, United Kingdom, S65 2EN

Not Yet Recruiting

191

Sandbach GPs

Sandbach, United Kingdom, CW11 1EQ

Not Yet Recruiting

192

Panthera Biopartners Limited - Sheffield

Sheffield, United Kingdom, S2 5FX

Not Yet Recruiting

193

Staploe Medical Centre

Soham, United Kingdom, ELY CB75JD

Not Yet Recruiting

194

Bodyline Medical Clinic Stoke on Trent

Stoke-on-Trent, United Kingdom, ST1 5TL

Not Yet Recruiting

195

Futuremeds Teesside Middlefield Centre University Hospital of North Tees

Teeside, United Kingdom, TS19 8PE

Not Yet Recruiting

196

Panthera Biopartners Limited - York

York, United Kingdom, YO24 4LJ

Not Yet Recruiting

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Research Team

P

Pfizer CT.gov Call Center

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

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