A protocol for a randomized controlled trial of exposure and response prevention for veterans with obsessive compulsive disorder.
Gabriella T Ponzini, Natalie E Hundt, Israel C Christie...
https://pubmed.ncbi.nlm.nih.gov/38237674Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID05240924
Exposure and Response Prevention to Improve Functioning in Veterans With Obsessive Compulsive Disorder
Led by VA Office of Research and Development · Updated on 2026-06-08
160
Participants Needed
19
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
This research aims to compare the impact of Exposure and Response Prevention (ERP) therapy versus a stress management training control on Veterans with Obsessive Compulsive Disorder (OCD), including those with both OCD and posttraumatic stress disorder (PTSD). The study will evaluate how these treatments affect Veterans' functioning, quality of life, and OCD symptoms. Additionally, the study will explore the potential for implementing ERP in Veterans Affairs (VA) mental health settings through mixed-methods evaluation. Participants will be randomly assigned to receive either 16 weekly sessions of ERP or 16 weekly sessions of stress management training, both delivered via video telehealth (VTH). ERP sessions, lasting 90 minutes each, involve psychoeducation, assessment, exposures to feared situations, and homework assignments focused on coping with OCD triggers. Stress management training includes psychoeducation and sessions teaching relaxation and coping skills. Assessments will be conducted after treatment and six months later. ERP participants will also provide feedback on treatment satisfaction and participate in qualitative interviews. Veterans will be involved in completing assessments of their work and social adjustment, quality of life, and OCD symptoms at baseline, post-treatment, and six months post-treatment. Researchers will collect data on treatment effects and implementation potential. Therapy sessions will be audio-recorded. The total participation lasts through treatment and follow-up visits up to six months after treatment completion.
CONDITIONS
Brief Title
ERP to Improve Functioning in Veterans With OCD
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Veterans with a primary diagnosis of Obsessive Compulsive Disorder (OCD) or comorbid OCD and Post-traumatic Stress Disorder (PTSD)
- Receiving care from specified VA Medical Centers or Clinical Resource Hubs
- Willingness to participate in Exposure and Response Prevention (ERP) therapy
You will not qualify if you...
- Significant cognitive impairment or conditions threatening safety such as current psychosis, mania, or imminent suicidality including plan or intent
- Moderate to severe substance use interfering with treatment
- Psychotropic medication dose not stable for at least 6 weeks prior to enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or virtual)
Treatment
Duration - Up to 6 months to complete treatment
Participants receive either 16 weekly sessions of Exposure and Response Prevention (ERP) therapy or 16 weekly sessions of stress management training delivered via video telehealth. These sessions include psychoeducation, skill building, and homework assignments to support managing OCD symptoms.
Weekly sessions for up to 16 weeks
Follow-up
Duration - 6 months after treatment completion
Participants complete assessments at post-treatment and 6 months after completing treatment to evaluate changes in functioning, quality of life, and OCD symptoms.
2 assessment visits after treatment
Trial Site Locations
Total: 19 locations
1
East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ
East Orange, New Jersey, United States, 07018
Actively Recruiting
2
VA Western New York Healthcare System, Buffalo, NY
Buffalo, New York, United States, 14215-1129
Actively Recruiting
3
VA NY Harbor Healthcare System, New York, NY
New York, New York, United States, 10010-5011
Actively Recruiting
4
Northport VA Medical Center, Northport, NY
Northport, New York, United States, 11768-2200
Actively Recruiting
5
James J. Peters VA Medical Center, Bronx, NY
The Bronx, New York, United States, 10468-3904
Actively Recruiting
6
Asheville VA Medical Center, Asheville, NC
Asheville, North Carolina, United States, 28805-2576
Actively Recruiting
7
Durham VA Medical Center, Durham, NC
Durham, North Carolina, United States, 27705-3875
Actively Recruiting
8
Fayetteville VA Medical Center, Fayetteville, NC
Fayetteville, North Carolina, United States, 28301-3856
Actively Recruiting
9
Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC
Salisbury, North Carolina, United States, 28144
Actively Recruiting
10
VA Roseburg Healthcare System, Roseburg, OR
Roseburg, Oregon, United States, 97471
Actively Recruiting
11
VA Southern Oregon Rehabilitation Center and Clinics, White City, OR
White City, Oregon, United States, 97503
Actively Recruiting
12
Ralph H. Johnson VA Medical Center, Charleston, SC
Charleston, South Carolina, United States, 29401-5703
Actively Recruiting
13
Michael E. DeBakey VA Medical Center, Houston, TX
Houston, Texas, United States, 77030-4211
Actively Recruiting
14
Michael E. DeBakey VA Medical Center, Houston, TX
Houston, Texas, United States, 77030-4211
Actively Recruiting
15
Hampton VA Medical Center, Hampton, VA
Hampton, Virginia, United States, 23667
Actively Recruiting
16
Hunter Holmes McGuire VA Medical Center, Richmond, VA
Richmond, Virginia, United States, 23249-0001
Actively Recruiting
17
Salem VA Medical Center, Salem, VA
Salem, Virginia, United States, 24153-6404
Actively Recruiting
18
Spokane VA Medical Center, Spokane, WA
Spokane, Washington, United States, 99205-6185
Actively Recruiting
19
Jonathan M. Wainwright Memorial VA Medical Center, Walla Walla, WA
Walla Walla, Washington, United States, 99362-3975
Actively Recruiting
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Research Team
T
Terri L Fletcher, PhD
M
Matthew G Escamilla, BS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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