Actively Recruiting
ERP to Improve Functioning in Veterans With OCD
Led by VA Office of Research and Development · Updated on 2025-11-13
160
Participants Needed
18
Research Sites
190 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no randomized controlled trials (RCTs) have examined the effectiveness of ERP among Veterans or individuals with both OCD and posttraumatic stress disorder (PTSD). This 4-year Hybrid Type I trial will compare outcomes of ERP to those of a control condition among Veterans with OCD. Primary and secondary aims will examine whether Veterans' functioning, quality of life, and OCD symptoms differ between the ERP and control in the full sample of Veterans with OCD, and in the half of the sample with both OCD and PTSD. The tertiary aim is to conduct a mixed-methods formative evaluation of the implementation potential of ERP in VA mental health settings.
CONDITIONS
Official Title
ERP to Improve Functioning in Veterans With OCD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans with a primary diagnosis of Obsessive Compulsive Disorder (OCD) or comorbid OCD and Post-traumatic Stress Disorder (PTSD)
- Receiving care at specified VA medical centers or telehealth hubs
- Willingness to participate in Exposure and Response Prevention (ERP) therapy
You will not qualify if you...
- Significant cognitive impairment or conditions that threaten safety such as current psychosis, mania, or imminent suicidality including plan or intent
- Moderate to severe substance use that interferes with treatment
- Psychotropic medications not on a stable dose for at least 6 weeks prior to enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 18 locations
1
East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ
East Orange, New Jersey, United States, 07018
Actively Recruiting
2
VA Western New York Healthcare System, Buffalo, NY
Buffalo, New York, United States, 14215-1129
Actively Recruiting
3
VA NY Harbor Healthcare System, New York, NY
New York, New York, United States, 10010-5011
Actively Recruiting
4
Northport VA Medical Center, Northport, NY
Northport, New York, United States, 11768-2200
Actively Recruiting
5
James J. Peters VA Medical Center, Bronx, NY
The Bronx, New York, United States, 10468-3904
Actively Recruiting
6
Asheville VA Medical Center, Asheville, NC
Asheville, North Carolina, United States, 28805-2576
Actively Recruiting
7
Durham VA Medical Center, Durham, NC
Durham, North Carolina, United States, 27705-3875
Actively Recruiting
8
Fayetteville VA Medical Center, Fayetteville, NC
Fayetteville, North Carolina, United States, 28301-3856
Actively Recruiting
9
Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC
Salisbury, North Carolina, United States, 28144
Actively Recruiting
10
VA Roseburg Healthcare System, Roseburg, OR
Roseburg, Oregon, United States, 97471
Actively Recruiting
11
VA Southern Oregon Rehabilitation Center and Clinics, White City, OR
White City, Oregon, United States, 97503
Actively Recruiting
12
Ralph H. Johnson VA Medical Center, Charleston, SC
Charleston, South Carolina, United States, 29401-5703
Actively Recruiting
13
Michael E. DeBakey VA Medical Center, Houston, TX
Houston, Texas, United States, 77030-4211
Actively Recruiting
14
Hampton VA Medical Center, Hampton, VA
Hampton, Virginia, United States, 23667
Actively Recruiting
15
Hunter Holmes McGuire VA Medical Center, Richmond, VA
Richmond, Virginia, United States, 23249-0001
Actively Recruiting
16
Salem VA Medical Center, Salem, VA
Salem, Virginia, United States, 24153-6404
Actively Recruiting
17
Spokane VA Medical Center, Spokane, WA
Spokane, Washington, United States, 99205-6185
Actively Recruiting
18
Jonathan M. Wainwright Memorial VA Medical Center, Walla Walla, WA
Walla Walla, Washington, United States, 99362-3975
Actively Recruiting
Research Team
M
Matthew G Escamilla, BS
CONTACT
T
Terri L Fletcher, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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