Study of New Low-Radiation CT Imaging Methods for Heart and Blood Vessel Disease Using Advanced Cardiac CT Angiography to Detect and Monitor Coronary Disease

What this Trial Is About

Researchers are evaluating new radiation techniques for cardiac CT angiography to reduce radiation exposure while maintaining accuracy in imaging the heart and blood vessels. The study focuses on whether these low-dose imaging methods can accurately predict patient outcomes and monitor the progression of coronary artery disease. It also assesses updated cardiac imaging software and artificial intelligence tools compared to standard images. Participants will undergo cardiac CT scans using the Cannon Aquilion ONE CT system, which employs low-radiation dose methods for coronary angiography. The study involves a single group of adults with a clinical indication for coronary CT angiography. Scans may include the use of a contrast agent and can last up to two hours. Follow-up contacts, including telephone or office visits, may occur depending on initial scan results to check for further cardiovascular testing or events. During the study, participants have physical exams, medical history reviews, and blood tests to check kidney function before imaging. Researchers will compare cardiovascular events in participants based on coronary artery stenosis levels and evaluate the quality and diagnostic accuracy of new CT technologies against standard methods. The study includes ongoing monitoring for clinical events and radiation dose comparisons. Participation may last several years until the study completion date in 2027.

Evaluating New Radiation Techniques for Cardiovascular Imaging