Actively Recruiting
A Randomized Double-Blind Trial Comparing Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery
Led by Ain Shams University · Updated on 2025-02-21
75
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare the effects of lidocaine and dexmedetomidine infusions, alone and combined, on pain management during and after video-assisted thoracoscopic surgery (VATS). VATS is a minimally invasive surgery that reduces surgical stress, but managing pain after the procedure is important to prevent complications and promote faster recovery. The study evaluates how these drugs influence postoperative pain, opioid use, nausea, vomiting, and recovery speed. Participants will be randomly assigned to one of three groups: one receiving lidocaine infusion, one receiving dexmedetomidine infusion, and one receiving both lidocaine and dexmedetomidine infusions. The infusions are given starting after anesthesia induction and continue until 10 minutes before the end of the surgery, with specific loading doses and maintenance rates for each drug. Saline infusions are used as placebos in the single-drug groups to maintain blinding. During the study, researchers will monitor participants for 24 hours after surgery, measuring total morphine use, time to extubation, time until first request for additional pain relief, pain levels, patient satisfaction, and any adverse events. The study uses a double-blind design to ensure unbiased results. Participants will be observed closely during this period to assess the effects of the treatments on their postoperative recovery and pain management.
CONDITIONS
Brief Title
Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Both sexes
- American Society of Anesthesiologists (ASA) physical status I or II
- Patients undergoing video-assisted thoracoscopic surgery under general anesthesia
You will not qualify if you...
- Hypersensitivity to any of the study drugs
- Coagulation disorder
- Body mass index greater than 35 kg/m2
- History of chronic pain requiring daily opioids, steroids, clonidine, or other similar drugs in the previous 2 weeks
- Drug or alcohol abuse
- Contraindication to local anesthetics
- Cardiovascular disease
- Severe respiratory, renal, or hepatic impairment
- Insulin-dependent diabetes mellitus
- Central nervous system or psychiatric disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of the surgery and immediate post-operative period
Participants undergo video-assisted thoracoscopic surgery and receive study drug infusions (lidocaine, dexmedetomidine, or their combination) during the operation until 10 minutes before the end of surgery.
1 visit (in-person)
Duration - 24 hours postoperatively
Participants are monitored for pain, opioid consumption, time of extubation, time to first rescue analgesia, patient satisfaction, and adverse events during the 24 hours after surgery.
Approximately 1 follow-up visit (in-person) within 24 hours after surgery
Trial Site Locations
Total: 1 location
1
Ain Shams University
Cairo, Egypt, 11591
Actively Recruiting
Research Team
S
Sarah A Afifi, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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