Sohag 2

This trial studies patients with uncomplicated rhegmatogenous retinal detachment to compare two different timings of internal limiting membrane ILM peeling during eye surgery. The research aims to understand whether peeling the ILM during the first surgery or delaying it until the time of silicon oil removal affects outcomes. The study is randomized and triple-masked, led by Sohag University. Participants will receive 23-gauge pars plana vitrectomy PPV with silicon oil tamponade. They will be randomly assigned to one of two groups Group A will have ILM peeling performed during the initial surgery, while Group B will have ILM peeling delayed until the silicon oil is removed. Both groups receive the same PPV and silicon oil treatment. During the study, patients will be followed from enrollment until three months after surgery to monitor for complications. The main outcome measured is the incidence of complications within this period. Participants will undergo regular postoperative evaluations to assess safety and treatment effects throughout the follow-up time. Total participation duration covers from surgery through three months post-operation.

Diffuse large B-cell lymphoma DLBCL is the most common and aggressive subtype of non-Hodgkin lymphoma, with rapid tumor growth and symptoms varying by tumor location. The disease is classified using advanced methods like immunohistochemistry and molecular testing to guide prognosis and personalized treatment. Despite standard immunochemotherapy curing 60-70% of patients, many experience treatment failure or relapse, and options after second-line therapies remain limited. This observational study examines treatment patterns, demographic, and clinical characteristics of DLBCL patients in the Middle East and Africa. It includes two patient groups those newly diagnosed and eligible for treatment, and those with relapsed or refractory DLBCL who have failed previous therapies. The study aims to explore access to novel therapies and understand real-world treatment approaches in these regions. Participants will be observed over 22 months, during which researchers will document treatment regimens, patient risk profiles, and access to new treatments. Data collection includes patient demographics, disease characteristics, and treatment outcomes. The study does not involve experimental treatments but gathers detailed information to inform future care strategies for DLBCL patients.

This research focuses on women with a history of previous abdominal surgeries who are scheduled for elective laparoscopy. It aims to evaluate how accurately transabdominal ultrasound can detect intraperitoneal adhesions before surgery. Laparoscopy is considered the gold standard for visualizing these adhesions, and the study investigates whether ultrasound can help ensure the safety of the initial trocar insertion. Participants will undergo transabdominal ultrasound using the sliding sign technique before their laparoscopic surgery. The ultrasound results will be compared to findings during laparoscopy to assess how well the ultrasound detects adhesions. This observational study includes women with prior laparotomies, transverse suprapubic or midline incisions, and cesarean sections. During the study, researchers will collect data from patient selection through the laparoscopic operation itself. They will measure sensitivity, specificity, positive predictive value, and negative predictive value of the ultrasound sliding sign in detecting intraperitoneal adhesions. The study is sponsored by Sohag University and will last until August 2026, with participation involving diagnostic ultrasound and laparoscopy to confirm adhesion presence and type.

Cerebrovascular stroke is a leading cause of death and disability worldwide, with atherosclerosis being a major cause of ischemic strokes through vessel narrowing and blockages. Intracranial stenosis often results in recurrent ischemic strokes or transient ischemic attacks, and its severity can influence the extent of brain injury. The prevalence of intracranial arterial stenosis varies among ethnic groups and is notably common in the Egyptian stroke population. Researchers are evaluating the accuracy of transcranial colour coded duplex, a non-invasive ultrasound tool that measures blood flow velocity and detects blockages in intracranial arteries, compared with CT angiography in patients with acute ischemic strokes or transient ischemic attacks. The study includes patients admitted to the neurology and stroke unit at Sohag University Hospital. Participants will undergo transcranial colour coded duplex and CT angiography to detect arterial obstructions. The study aims to assess the accuracy of the duplex method one year after enrolling 100 patients. Researchers will monitor cerebral blood flow and arterial blockage detection, with no invasive procedures beyond routine imaging. The total participation duration varies but includes comprehensive diagnostic assessments to compare these imaging techniques.

Beta-thalassemias are inherited blood disorders causing chronic anemia due to problems with hemoglobin production. The severity varies, influencing the need for regular blood transfusions. This research focuses on patients with beta-thalassemia, especially those dependent on transfusions, and evaluates their adherence to oral iron chelation therapy, which is crucial for managing iron overload. The study is sponsored by Sohag University and aims to understand treatment compliance in children and adolescents aged 2 to 18 years. Participants in this study are patients with beta-thalassemia major or intermedia who have been receiving regular blood transfusions every 2 to 5 weeks. They are prescribed oral iron chelation therapy using deferasirox, which they must have taken for at least one year before joining the study. The study follows these patients over one year to monitor their serum ferritin levels, a marker of iron in the body, to assess adherence to the oral treatment. During the study, participants will have their ferritin levels regularly checked to monitor how well they follow the oral therapy. Researchers will also observe any side effects or complications related to the treatment. The total participation period is one year, during which the patients iron levels and overall management will be closely reviewed to better understand real-world adherence to oral chelation therapy in this population.

Researchers are studying the potential of using a combination of the albumin to globulin ratio AGR and the prognostic nutritional index PNI as a predictive tool for disease activity in patients with systemic lupus erythematosus SLE. This observational study aims to correlate these nutritional and inflammatory markers with clinical signs and laboratory results to develop a simple, non-invasive, and cost-effective way to monitor SLE activity. Participants will include patients with active SLE who meet specific classification criteria, as well as healthy individuals matched by age and sex for comparison. The study involves measuring the albumin to globulin ratio and prognostic nutritional index in these participants to assess their disease activity. The primary outcome is to evaluate the usefulness of AGR as a reliable biomarker for predicting disease activity over a period from six months to one year. During the study, participants will undergo assessments including laboratory tests to measure AGR and PNI. Researchers will track these markers alongside clinical manifestations and other laboratory parameters. The study will monitor outcomes over time to determine if these markers can effectively predict disease activity in SLE. Participation duration and follow-up plans will align with the study timeline ending in June 2026.

Researchers are evaluating the functional outcomes of patients who have undergone successful finger replantation after traumatic digit injuries. The study focuses on measuring how well the finger functions using both objective tests like grip strength, range of motion, and sensory recovery, and subjective reports from patients about pain, satisfaction, and daily activity performance. Various scoring systems are used to standardize assessments, recognizing that success depends on restoring function beyond just saving the finger. This observational study looks at patients with multiple digit replantations. It does not involve any treatment interventions but collects data on hand function at least six months after replantation. The main measurements include finger flexion and extension, grip and pinch strength, range of motion, sensory recovery, pain intensity, and the DASH score, which reflects disability of the arm, shoulder, and hand. Participants will undergo assessments at least six months post-replantation to evaluate their finger function and recovery. These include physical tests of movement and strength, sensory testing, and questionnaires about pain and daily function. The study tracks these outcomes to better understand how well replantation restores hand function after traumatic amputation, with the total participation period depending on the timing of the follow-up evaluations.

Researchers are evaluating important blood-based indices in children diagnosed with juvenile systemic lupus erythematosus SLE. The study aims to understand if these hematologic markers relate to the activity of the disease and the level of chronic organ damage in these young patients. This observational study is led by Sohag University and focuses on identifying clinical correlations that might help monitor disease progression. The study involves calculating several hematologic indices such as the systemic inflammatory index, systemic inflammatory response index, and the aggregate index of systemic inflammation in children with juvenile SLE. These markers will then be compared with the SLE disease activity index and the chronic damage index to explore their relationship with disease severity and long-term damage. Participants will be evaluated during the study period of 3 to 6 months, during which researchers will measure blood markers and assess disease activity and organ damage using standard indices. The main outcomes include the calculation of hematologic indices and their correlation with disease activity and chronic damage. The study is observational, meaning no treatments are given, but careful monitoring and data collection will occur to gather meaningful clinical information.

This research aims to assess kidney function in children with epilepsy who attend Sohag University Hospital. It focuses on evaluating the effects of long-term antiepileptic drug AED use on kidney health by measuring various renal biochemical markers, liver functions, urinalysis, and conducting abdominal ultrasound exams. The study includes pediatric patients with idiopathic epilepsy receiving different AED regimens to understand how these medications may impact kidney function. The study is observational and involves collecting clinical data and laboratory test results without administering experimental treatments. Researchers will gather baseline information such as medical history, seizure type, frequency, current medications, and demographic details. Blood samples will be taken to measure serum creatinine, alongside other tests like CBC, electrolytes, arterial blood gases, urinalysis, EEG, and abdominal ultrasound to evaluate kidney and liver function. Participants will be assessed once at enrollment with a single cross-sectional evaluation including physical exams and multiple laboratory tests. The main outcome measured is serum creatinine level, while secondary outcomes include identifying kidney stones, electrolyte imbalances, abnormal urine findings, and abdominal ultrasound results. The study aims to understand the relationship between AED therapy and kidney health in children with epilepsy to guide future monitoring and management.

Researchers are studying retinal microvascular changes in adults with diabetic retinopathy using optical coherence tomography angiography OCTA, a non-invasive imaging method that provides detailed views of the retinal blood vessels. The study aims to understand how these retinal vessel changes relate to visual acuity and blood sugar control HbA1c across different stages of diabetic retinopathy, which is a leading cause of vision loss worldwide. Participants diagnosed with diabetic retinopathy will undergo detailed eye exams including best-corrected visual acuity testing, fundus examination, OCT, and OCT angiography. Retinal vessel density in the superficial and deep capillary layers and the size of the foveal avascular zone will be measured. Blood sugar control will be assessed by recording HbA1c levels. This cross-sectional observational study will be conducted at Sohag Universitys Department of Ophthalmology. During the study, participants will receive a comprehensive eye assessment and blood sugar evaluation. Researchers will analyze retinal microvascular parameters and look for correlations with vision and HbA1c values. The main goal is to measure retinal changes by OCTA at baseline and explore their clinical significance. The study does not involve treatment and participation lasts for the duration of the evaluation visit.