Actively Recruiting
Multimodal Electrophysiological Study of Cortico-subcortical Biomarkers of Tics in Tourette Syndrome
Led by University Hospital, Bordeaux · Updated on 2025-04-03
10
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Tourette syndrome (TS) is a complex neurodevelopmental disorder marked by involuntary movements and vocalizations called tics. It begins in childhood and affects about 0.3 to 0.9% of people under 18, often accompanied by psychiatric conditions like ADHD and OCD. The cause is thought to involve genetic and environmental factors, with brain circuit dysfunctions playing a key role. Deep brain stimulation (DBS) is an invasive treatment option for severe, drug-resistant TS, but current continuous DBS methods may cause side effects or be less effective due to lack of adaptability. This research aims to identify brain activity patterns linked to tics to improve DBS methods.
CONDITIONS
Brief Title
Multimodal Electrophysiological Study of Cortico-subcortical Biomarkers of Tics in Tourette Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient at least 16 years old
- Disabling and drug-resistant Tourette's syndrome
- Receiving deep brain stimulation treatment with implantation of the PERCEPT™ Device as part of their medical management
- Normal brain MRI
- Affiliated or beneficiary of a social security system
- Free and informed consent of the patient and, for minors, of the minor and at least one parental authority
You will not qualify if you...
- Major depressive syndrome (Beck Depression Inventory (BDI-II) > 20)
- MRI showing significant brain atrophy or significant hyperintensities
- Pregnant or nursing mothers
- Person unable to give personal consent
- Person subject to a legal protection measure (curatorship, guardianship) or placed under court protection
- Patient included in another research protocol with an interdiction of participation to another research or in an exclusion period
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single session
Participants undergo multimodal electrophysiological recordings including local field potentials, high-resolution electroencephalogram, and electromyogram coupled with video analysis during experimental conditions involving uncontrolled tics and voluntary tic-like movements.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
CHU de Bordeaux
Bordeaux, France, 33076
Actively Recruiting
Research Team
E
Edouard COURTIN, Dr
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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