Design, methods, and conduct of the Optic Neuritis Treatment Trial.
P A Cleary, R W Beck, M M Anderson...
https://pubmed.ncbi.nlm.nih.gov/8500302Status Unknown
Phase 3
Age: 18Years - 46Years
All Genders
ID00000146
Optic Neuritis Treatment Trial (ONTT)
Led by National Eye Institute (NEI) · Updated on 2006-06-05
N/A
Participants Needed
15
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
To assess the beneficial and adverse effects of corticosteroid treatment for optic neuritis. To determine the natural history of vision in patients who suffer optic neuritis. To identify risk factors for the development of multiple sclerosis in patients with optic neuritis.
CONDITIONS
Brief Title
Optic Neuritis Treatment Trial (ONTT)
Who Can Participate
Age: 18Years - 46Years
All Genders
Eligibility Criteria
You may qualify if you...
The major eligibility criteria for enrollment into the ONTT included the following:
Age range of 18 to 46 years
Acute unilateral optic neuritis with visual symptoms for 8 days or less
A relative afferent pupillary defect and a visual field defect in the affected eye
No previous episodes of optic neuritis in the affected eye
No previous corticosteroid treatment for optic neuritis or multiple sclerosis
No systemic disease other than multiple sclerosis that might be the cause of the optic neuritis
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 15 locations
1
University of Arkansas
Little Rock, Arkansas, United States
Status Unknown
2
California Pacific Medical Center
San Francisco, California, United States
Status Unknown
3
Georgetown University
Washington D.C., District of Columbia, United States
Status Unknown
4
University of Florida
Gainesville, Florida, United States
Status Unknown
5
University of Illinois
Chicago, Illinois, United States
Status Unknown
6
University of Iowa
Iowa City, Iowa, United States
Status Unknown
7
Johns Hopkins University
Baltimore, Maryland, United States
Status Unknown
8
University of Michigan
Ann Arbor, Michigan, United States
Status Unknown
9
Michigan State University
East Lansing, Michigan, United States
Status Unknown
10
New York University
New York, New York, United States
Status Unknown
11
Duke University
Durham, North Carolina, United States
Status Unknown
12
Devers Eye Institute
Portland, Oregon, United States
Status Unknown
13
Wills Eye Hospital
Philadelphia, Pennsylvania, United States
Status Unknown
14
Baylor College of Medicine
Houston, Texas, United States
Status Unknown
15
Swedish Medical Center
Seattle, Washington, United States
Status Unknown
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
N/A
Primary Purpose
TREATMENT
Number of Arms
0
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Published Research Related To This Trial
Quality control functions of the Visual Field Reading Center (VFRC) for the Optic Neuritis Treatment Trial (ONTT).
J L Keltner, C A Johnson, R W Beck...
https://pubmed.ncbi.nlm.nih.gov/8500303Remote clinic/patient monitoring for multicenter trials. Optic Neuritis Study Group.
M M Anderson, L D Boly, R W Beck
https://pubmed.ncbi.nlm.nih.gov/8932973Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group.
https://pubmed.ncbi.nlm.nih.gov/9400788The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group.
https://pubmed.ncbi.nlm.nih.gov/1841573A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
R W Beck, P A Cleary, M M Anderson...
https://pubmed.ncbi.nlm.nih.gov/1734247Corticosteroid treatment of optic neuritis: a need to change treatment practices. The Optic Neuritis Study Group.
R W Beck
https://pubmed.ncbi.nlm.nih.gov/1318520The optic neuritis treatment trial. Implications for clinical practice. Optic Neuritis Study Group.
R W Beck
https://pubmed.ncbi.nlm.nih.gov/1543448Brain magnetic resonance imaging in acute optic neuritis. Experience of the Optic Neuritis Study Group.
R W Beck, J Arrington, F R Murtagh...
https://pubmed.ncbi.nlm.nih.gov/8352671Optic neuritis treatment trial. One-year follow-up results.
R W Beck, P A Cleary
https://pubmed.ncbi.nlm.nih.gov/8512477