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Actively Recruiting

Phase Not Applicable
Age: 6Years - 16Years
All Genders
ID04040920

Study on Using Ozone Treatment Before Applying Fissure Sealants to Protect Childrens Molars

Led by IRCCS Burlo Garofolo · Updated on 2025-05-16

67

Participants Needed

1

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Dental decay is a complex disease affecting the hard tissues of teeth, mainly caused by bacteria like Streptococcus mutans and Lactobacillus forming biofilm on tooth surfaces. This decay usually occurs in the grooves and pits of secondary molars. Sealants placed in these pits and fissures can prevent decay if applied within two years after the tooth erupts. Ozone therapy, which has bactericidal and enamel remineralizing properties, is being studied to see if applying it before sealants can help sealants last longer. The study compares the use of ozone applied with the OzoneDTA device for one minute before placing pits and fissure sealants. The sealant procedure includes cleaning the tooth surface, etching with orthophosphoric acid, drying, applying the sealant material, and polymerizing it. Participants receive sealants with and without ozone pretreatment in a randomized, split-mouth design to evaluate the effect of ozone on sealant longevity. During the study, researchers will monitor sealant failures at 6, 12, and 24 months after placement, as well as any secondary decay in failed sealants. Participants will have their first or second secondary molars sealed and isolated using a rubber dam. The study includes assessments of sealant condition and dental health over two years to measure the durability and effectiveness of the treatments under study.

CONDITIONS

Brief Title

Ozone Application Before Fissure Sealants

Research Team

M

Milena Cadenaro, DDS,MSc,PhD

C

Chiara Navarra, DDS,MSc,PhD

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