Comparing Pregabalin and Dexmedetomidine for Treating Delirium After Coronary Artery Bypass Surgery in Older Adults

What this Trial Is About

Researchers are evaluating the effects of pregabalin versus dexmedetomidine on treating and prolonging the duration of delirium in elderly patients undergoing Coronary Artery Bypass Grafting CABG. Delirium is a sudden brain disorder affecting consciousness, attention, and perception, and it is common after cardiac surgery, especially in older adults. This study aims to compare these two drugs to understand their impact on postoperative delirium in patients aged 65 and older. Participants will be randomly assigned to receive either pregabalin capsules 75 mg every 12 hours for 24 hours through a nasogastric tube or a bolus dose of dexmedetomidine 0.4 gkg over 10 to 20 minutes followed by a continuous infusion of 0.2 to 0.7 ghour. The study is double-blind, meaning neither the participants nor the researchers know which treatment is being given. The trial focuses on fast-tracking elderly CABG patients for postoperative delirium treatment. During the study, researchers will monitor the percentage of patients with delirium treated 24 hours after surgery as the primary outcome. They will also assess sedation levels at 24 hours, the rate of weaning from mechanical ventilation within one week, and hospital stay length measured at one month postoperatively. Participants will be closely observed and evaluated through these measures to understand the treatments effects and safety over time.

Pregabalin Versus Dexmedetomidine for Delirium Treatment After Coronary Artery Bypass Grafting