Testing Computerized Cognitive Training to Prevent Mild Cognitive Impairment or Dementia in Adults 65 and Older

What this Trial Is About

Dementia, particularly Alzheimers disease, affects millions of older adults and is associated with significant health, quality-of-life, and economic challenges. Mild cognitive impairment MCI is an early stage that indicates higher risk for dementia. This trial aims to determine if computerized cognitive speed of processing training SPT can delay the onset of MCI or dementia over a three-year period. The study builds on previous findings that suggest cognitive training may reduce cognitive decline in older adults. The trial is a randomized clinical study enrolling 7,600 adults aged 65 and older. Participants will be randomly assigned to either computerized cognitive speed of processing training or an active comparator involving computerized cognitive stimulation. Each participant will complete 45 training sessions, including supervised in-person sessions and additional exercises done at home over 3 to 5 months. Booster training sessions will be given at one and two years after the initial training. Participants will undergo screening assessments including memory and depression evaluations, followed by psychometric testing, clinical diagnostic evaluations, MRI and PET scans, and genetic testing. Researchers will monitor adherence to training through supervised and at-home sessions. The main outcome measured is the incidence of mild cognitive impairment or dementia over three years. The study includes ongoing assessments to evaluate cognitive status and safety throughout the trial period.

Preventing Alzheimer's With Cognitive Training