Actively Recruiting
Preventing Alzheimer's With Cognitive Training
Led by University of South Florida · Updated on 2024-09-26
7600
Participants Needed
7
Research Sites
362 weeks
Total Duration
On this page
Sponsors
U
University of South Florida
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and is indicative of higher risk for dementia. In addition to the obvious health and quality-of-life ramifications of dementia, there are high direct (e.g., subsidizing residential care needs) and indirect (e.g., lost productivity of family caregivers) economic costs. Implementing interventions to prevent MCI and dementia among older adults is of critical importance to health and maintained quality-of-life for millions of Americans. Recent data analyses from the Advanced Cognitive Training in Vital Elderly study (ACTIVE) indicate that a specific cognitive intervention, speed of processing training (SPT), significantly delays the incidence of cognitive impairment across 10 years. The primary contribution of the proposed research will be the determination of whether this cognitive training technique successfully delays the onset of clinically defined MCI or dementia across three years.
CONDITIONS
Official Title
Preventing Alzheimer's With Cognitive Training
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be age 65 or older at time of consent
- Ability to speak and understand English or Spanish
- Adequate sensorimotor ability to perform computer exercises
- Adequate vision to read a computer screen at typical distance
- Adequate hearing to understand conversational speech
- Adequate motor skills to use a computer screen or mouse
- No evidence of mild cognitive impairment or dementia (Montreal Cognitive Assessment score 6 26)
- Adequate mental health without interfering mental illness
- Willingness to complete all study activities
- Ability to understand and comply with study procedures for the study duration
You will not qualify if you...
- Currently enrolled in another cognition-related clinical or treatment study
- Previous participation in a cognitive training study
- Vision, hearing, or motor problems interfering with study exercises
- Diagnosis of mild cognitive impairment, dementia, stroke, traumatic brain injury, brain tumor, or neurological disorder affecting cognition
- Unstable medical conditions likely to cause cognitive or functional decline
- Use of dementia medications such as Namenda, Memantine, Donepezil, Aricept, and others
- Completed 10+ hours of computerized cognitive training in last 5 years
- Severe depressive symptoms (Geriatric Depression Scale score 6 5)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
University of Florida
Gainesville, Florida, United States, 32611
Active, Not Recruiting
2
University of Florida
Jacksonville, Florida, United States, 32209
Active, Not Recruiting
3
University of North Florida
Jacksonville, Florida, United States, 32224
Terminated
4
The Roskamp Institute
Sarasota, Florida, United States, 34243
Actively Recruiting
5
University of South Florida
Tampa, Florida, United States, 33620
Actively Recruiting
6
Duke Health
Durham, North Carolina, United States, 27705
Actively Recruiting
7
Clemson University Institute for Engaged Aging
Seneca, South Carolina, United States, 29672
Actively Recruiting
Research Team
J
Jennifer L O'Brien, PhD
CONTACT
J
Jennifer Lister, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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