Actively Recruiting
Acute Effects of THC in Older Adult
Led by Yale University · Updated on 2025-08-18
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how increasing age affects the immediate impact of THC on memory, attention, psychomotor function, feelings of anxiety or reward, and heart rate and blood pressure in adults over 21 years old. The study also explores how age influences the brain's electrical activity during information processing and differences in THC metabolism. This trial is conducted by Yale University and is a Phase 1 randomized study. Participants receive either a low or medium dose of delta-9-THC or a placebo, all administered intravenously over 20 minutes. The placebo consists of a small amount of sterile ethanol without THC. Each test day includes two drug administration sessions where these treatments are given, allowing comparison of the effects at different doses and against placebo. During the study, participants will complete memory tests such as the Rey Auditory Verbal Learning Task approximately 25 minutes after each drug administration. They will also provide subjective feedback on various effects through Visual Analog Scales at multiple time points up to 420 minutes after infusion. The trial monitors cognitive, subjective, and cardiovascular responses to THC to understand age-related differences, with participation involving multiple assessments on test days.
CONDITIONS
Brief Title
Acute Effects of THC in Older Adult
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to provide informed consent
- No history (current or past) of unstable or serious medical, neurological or psychiatric conditions
- High school education or greater
- No positive pregnancy test and/or lactation/ planning to nurse while in this study
- English speaking
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Each test day involves two drug administration sessions with assessments up to 7 hours post-infusion.
Participants receive intravenous doses of Delta-9-THC or placebo in separate sessions with evaluations after each administration.
Each test day includes 2 intravenous infusions over 20 minutes each, with multiple assessments up to 7 hours after the first infusion.
Trial Site Locations
Total: 1 location
1
VA Connecticut Healthcare System
West Haven, Connecticut, United States, 06516
Actively Recruiting
Research Team
D
Deepak C D'Souza
A
Ashley Schnakenberg Martin, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
3
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