Study on How Age Affects the Immediate Impact of THC on Thinking, Feelings, and Heart Health in Adults Over 21

What this Trial Is About

Researchers are studying how increasing age affects the immediate impact of THC on memory, attention, psychomotor function, feelings of anxiety or reward, and heart rate and blood pressure in adults over 21 years old. The study also explores how age influences the brains electrical activity during information processing and differences in THC metabolism. This trial is conducted by Yale University and is a Phase 1 randomized study. Participants receive either a low or medium dose of delta-9-THC or a placebo, all administered intravenously over 20 minutes. The placebo consists of a small amount of sterile ethanol without THC. Each test day includes two drug administration sessions where these treatments are given, allowing comparison of the effects at different doses and against placebo. During the study, participants will complete memory tests such as the Rey Auditory Verbal Learning Task approximately 25 minutes after each drug administration. They will also provide subjective feedback on various effects through Visual Analog Scales at multiple time points up to 420 minutes after infusion. The trial monitors cognitive, subjective, and cardiovascular responses to THC to understand age-related differences, with participation involving multiple assessments on test days.

Acute Effects of THC in Older Adult