Actively Recruiting
Acute Effects of THC in Older Adult
Led by Yale University · Updated on 2025-08-18
60
Participants Needed
1
Research Sites
125 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults \> 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm \[P300\], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.
CONDITIONS
Official Title
Acute Effects of THC in Older Adult
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to provide informed consent
- No history (current or past) of unstable or serious medical, neurological or psychiatric conditions
- High school education or greater
- No positive pregnancy test and/or lactation or planning to nurse during the study
- English speaking
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 1 location
1
VA Connecticut Healthcare System
West Haven, Connecticut, United States, 06516
Actively Recruiting
Research Team
D
Deepak C D'Souza
CONTACT
A
Ashley Schnakenberg Martin, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
3
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