Actively Recruiting
Role of Spectral CT in Diagnosing Myocarditis and MINOCA in Patients with Acute Chest Pain Undergoing Cardiac CT
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-02-03
200
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on patients experiencing acute chest pain with a low to intermediate likelihood of coronary artery disease, where standard ECG and troponin tests are inconclusive or altered. It evaluates the use of a new imaging technology called Spectral CT to help identify causes of chest pain, including myocarditis and MINOCA (Myocardial Infarction with Non-Obstructive Coronary Arteries), conditions that are challenging to diagnose with conventional CT scans alone. The study is observational and cross-sectional, conducted at a single center using clinical and laboratory data alongside imaging. Participants will undergo CT examinations using Spectral CT technology, which is capable of detailed tissue characterization. This method generates specialized images that can detect features like extracellular volume, late iodine enhancement, hyperemia, and edema—potential signs of myocardial damage. The study aims to demonstrate whether Spectral CT can identify myocarditis or MINOCA in addition to excluding other causes of acute chest pain such as heart attack, pulmonary embolism, and aortic syndromes. During the study, participants will receive the Spectral CT scan as part of their clinical evaluation. Researchers will analyze the images and clinical data to measure how many cases of myocarditis or MINOCA are diagnosed using this technology within one week after the examination. The study involves no treatment interventions, and participants are observed through their diagnostic process. The research is sponsored by IRCCS Azienda Ospedaliero-Universitaria di Bologna and is expected to continue until February 2027.
CONDITIONS
Brief Title
Role of Spectral CT in the Diagnosis of Myocarditis/MINOCA in Patients Undergoing cardioCT Investigations for Acute Chest Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than or equal to 18 years
- Patients with acute chest pain and indication for triple-rule-out CT or coronary CT examination
- Low or intermediate probability of acute coronary artery disease
- ECG and/or troponin tests are non-diagnostic or altered
- Ability to provide informed consent
You will not qualify if you...
- Absolute contraindications to CT examination or iodinated contrast (e.g., pregnancy, severe kidney impairment with GFR < 15-30 ml/min/1.73m2 in non-dialysis patients)
- CT images that are too poor in quality for diagnosis due to artifacts such as motion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo Spectral CT imaging to evaluate myocardial tissue and diagnose causes of acute chest pain including myocarditis and MINOCA.
1 visit (in-person)
Duration - 1 week after examination
Participants are monitored for diagnosis outcomes following the Spectral CT examination.
1 follow-up contact
Trial Site Locations
Total: 1 location
1
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy, 40138
Actively Recruiting
Research Team
V
Vincenzo Russo, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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