Study of Non-invasive Methods to Detect Early Complications After Liver Transplant in Adults

What this Trial Is About

Liver transplantation can lead to various early and late complications, including surgical issues, infections, and immune-related problems like acute cellular rejection ACR. These complications often show changes in liver enzymes and liver function tests, which may result in early allograft dysfunction EAD. Currently, there is no reliable biomarker to predict the development of ACR or EAD after transplantation. This study aims to explore the role of non-invasive instrumental and biological markers during the early post-transplant period to better understand and predict these complications. This observational study involves monitoring liver transplant recipients using non-invasive methods to assess their liver function and detect possible complications. The study focuses on evaluating the prognostic value of these markers within the first two weeks after transplantation. There are no specific drug treatments or interventions assigned, as the study observes patients following standard transplant procedures and care. Participants will be followed closely in the early post-transplant phase, with assessments including liver enzyme levels and liver function tests. The main outcome measured is the occurrence of early allograft dysfunction within two weeks after liver transplantation. Researchers will collect and analyze non-invasive instrumental and biological marker data to understand their predictive value. The total duration of participation depends on the early post-transplant monitoring period, with safety and liver function continuously evaluated.

Single-center Prospective Study of Non-invasive Methods for the Diagnosis of Postoperative Complications in Liver Transplant Recipients