An 8-Week Study Comparing an Experimental Stannous Fluoride Toothpaste to Regular Fluoride Toothpaste for Reducing Gingivitis and Plaque

What this Trial Is About

Researchers are studying the effects of an experimental toothpaste containing 0.454% Stannous Fluoride SnF2 to see if it can reduce gingivitis and plaque buildup compared to a regular fluoride toothpaste. This study involves participants with mild to moderate gingivitis and aims to evaluate improvements in gum health over an 8-week period. It is a controlled, randomized, single-blind clinical trial conducted at a single center. Participants will be randomly assigned to one of two groups one group will use the experimental dentifrice and the other will use a regular fluoride toothpaste. Both groups are instructed to brush their teeth thoroughly for at least one minute twice daily using the provided toothpaste and toothbrush. The study lasts for 8 weeks with treatments applied twice daily. Throughout the study, participants will attend scheduled visits where their gum health and plaque levels will be assessed using standardized measures such as the Modified Gingival Index and the Turesky Modification of the Quigley Hein Plaque Index. Researchers will monitor changes from the baseline to week 8. Safety and adherence to the treatment plan will also be evaluated during the study period, which is expected to complete by October 2026.

A Study to Investigate the Efficacy of an Experimental Dentifrice Containing Stannous Fluoride in Improving Gingival Health