Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy: The GENETIC Study

What this Trial Is About

Acute stress-induced (takotsubo) cardiomyopathy, also known as broken heart syndrome, mimics a heart attack and is triggered by intense emotional or physical stress. This condition can have serious and potentially fatal consequences. Researchers are studying whether certain people have a genetic predisposition that makes them more likely to develop this condition, which could also affect their families. This investigation aims to better understand the underlying causes of this complex neuro-psycho-cardiac disorder. The study involves collecting blood samples from patients diagnosed with takotsubo cardiomyopathy, including those diagnosed in Scotland since 2010 and willing familial cases worldwide. The blood will be used for genetic analysis, including a large-scale genome wide association study to identify genetic factors linked to the condition. DNA samples will be stored for future research into candidate genetic variants. Participants will provide a blood sample at baseline for genetic testing. Researchers will analyze the genetic data to identify predisposition factors through the genome wide association study. This study does not involve treatments but focuses on collecting and studying genetic information. Participation may help advance knowledge of genetic risks related to takotsubo cardiomyopathy, with involvement lasting until the baseline genetic analysis is completed.

Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy