Actively Recruiting
Led by University of Coimbra · Updated on 2024-05-08
400
Participants Needed
1
Research Sites
126 weeks
Total Duration
U
University of Coimbra
Lead Sponsor
F
Fundação para a Ciência e a Tecnologia
Collaborating Sponsor
Researchers are evaluating a neuropsychological intervention called the REMINDER program designed to reduce the risk of dementia in older adults with increased risk. This study compares the REMINDER program to an active control group receiving psychoeducation about brain health and dementia risk factors. The trial aims to assess the effects of the program on cognitive function, daily functioning, neuropsychological measures, biomarkers, and dementia conversion rates over time. The REMINDER program involves 20 therapist-led sessions lasting 45 to 60 minutes, delivered twice weekly over 12 weeks. It includes personal development activities, cognitive compensatory aids, goal setting, and behavior change techniques. The program is delivered either online via videoconferencing or face-to-face, with group and individual sessions to encourage social support and skill training. The control group participates in 20 psychoeducation sessions of the same length and frequency. Participants will undergo assessments shortly after the intervention and at 6, 12, 18, and 24 months follow-up, including cognitive and functionality evaluations, blood biomarker tests, brain imaging, mood and quality of life measures, and self-efficacy questionnaires. Researchers will track adherence and measure the rate of progression from mild cognitive impairment to dementia. Total participation includes the 12-week intervention and extended follow-up for up to 24 months.
CONDITIONS
Validation of the REMINDER Dementia Risk Reduction Program
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote)
Duration - 12 weeks
Participants receive the REMINDER program or brain health psychoeducation sessions to promote cognitive reserve, socialization, and dementia risk reduction.
Twice weekly sessions totaling 20 sessions
Duration - Up to 24 months after the intervention
Participants are monitored for lasting effects on cognition, functionality, mood, and quality of life after the intervention.
Assessments at 1 week, 12 months, and 24 months post intervention
Total: 1 location
1
Faculty of Psychology and Educational Sciences
Coimbra, Portugal, 3002-115
Actively Recruiting
A
Ana Rita Silva, PhD
U
University of Coimbra
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
3
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Ana Rita Silva, Catarina Baptista, Inês Baldeiras...
https://pubmed.ncbi.nlm.nih.gov/41366742