Testing the REMINDER Multidomain Neuropsychological Program for Adults 60 to 75 at Risk of Dementia

What this Trial Is About

Researchers are evaluating a neuropsychological intervention called the REMINDER program designed to reduce the risk of dementia in older adults with increased risk. This study compares the REMINDER program to an active control group receiving psychoeducation about brain health and dementia risk factors. The trial aims to assess the effects of the program on cognitive function, daily functioning, neuropsychological measures, biomarkers, and dementia conversion rates over time. The REMINDER program involves 20 therapist-led sessions lasting 45 to 60 minutes, delivered twice weekly over 12 weeks. It includes personal development activities, cognitive compensatory aids, goal setting, and behavior change techniques. The program is delivered either online via videoconferencing or face-to-face, with group and individual sessions to encourage social support and skill training. The control group participates in 20 psychoeducation sessions of the same length and frequency. Participants will undergo assessments shortly after the intervention and at 6, 12, 18, and 24 months follow-up, including cognitive and functionality evaluations, blood biomarker tests, brain imaging, mood and quality of life measures, and self-efficacy questionnaires. Researchers will track adherence and measure the rate of progression from mild cognitive impairment to dementia. Total participation includes the 12-week intervention and extended follow-up for up to 24 months.

Validation of the REMINDER Dementia Risk Reduction Program