Evaluation of Pomegranate Peel Extract Gel with Scaling and Root Planing for Adults with Stage II-III Periodontitis Ages 30 to 60

What this Trial Is About

Researchers are evaluating the effectiveness of a subgingival pomegranate peel extract gel as an addition to standard scaling and root planing SRP treatment for adults with Stage II-III periodontitis. This randomized, triple-blind, placebo-controlled trial involves 32 participants diagnosed with this periodontal condition to assess whether the gel improves healing and clinical outcomes compared to SRP alone. Participants will receive SRP in all selected periodontal sites. The test sites will be treated with the pomegranate peel extract gel applied under the gums, while the control sites will receive a placebo gel that looks and feels the same. Clinical measures such as probing pocket depth, attachment level, plaque, gingival indices, and bleeding on probing will be recorded at baseline, 1 month, 3 months, and 6 months. Gingival crevicular fluid will also be collected to measure levels of matrix metalloproteinase-8, an enzyme related to tissue breakdown. During the study, participants will attend follow-up visits at the specified time points for clinical assessments and fluid sample collection. Researchers will monitor changes in periodontal health and biochemical markers over six months to evaluate the added effect of the pomegranate peel extract gel. This careful monitoring aims to provide detailed information on the gels potential role in enhancing periodontal treatment outcomes.

Adjunctive Subgingival Pomegranate Peel Extract Gel for Stage II-III Periodontitis