Actively Recruiting
Cytomegalovirus Reactivation in ICU Patients Requiring Prolong Mechanical Ventilation
Led by Sanjay Gandhi Postgraduate Institute of Medical Sciences · Updated on 2024-07-26
125
Participants Needed
1
Research Sites
83 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cytomegalovirus (CMV) is a latent infection virus that is widespread in the population. CMV may reactivate under certain circumstances, and its hazardous nature has been proven, especially in immunosuppressed patients. However in recent years, some studies have found that CMV reactivation also exists in apparently immunocompetent patients during their critical illness. In these non-immunosuppressed patients, the presence of sepsis and its immunomodulatory effects may lead to reactivation of dormant viral infections. Studies found the incidence of CMV reactivation in up to one-fourth to half of these non-immunosuppressed patients during their critical illness. These studies also documented significantly higher length of ICU stay and mortality in critically ill patients with CMV reactivation. CMV reactivation has also been studied in specific critically ill cohorts, exhibiting there impact on mortality. David S Y Yong et al studied the effect of CMV reactivation on mortality in immunocompetent acute respiratory distress syndrome (ARDS) patients. In a recent study, it was found that among cohort of non-immunosuppressed patients with acute respiratory distress syndrome (ARDS), CMV reactivation occurred in 27 % of patients which was associated with overall increased ICU mortality. In another study among septic shock cohort (329 patients), herpesvirus reactivations were documented in 68% patients without prior immunodeficiency and concluded that reactivations could be independently associated with mortality. However currently, no study is available investigating the CMV reactivation and it's kinetics during critical illness in non immunocompetent patients requiring prolonged mechanical ventilation. In this planned observational study, we aim to find out the prevalence of Cytomegalovirus (CMV) reactivation, viral load and it's association with the severity of illness in non immunosuppressed ICU patients requiring prolong mechanical ventilation.
CONDITIONS
Official Title
Cytomegalovirus Reactivation in ICU Patients Requiring Prolong Mechanical Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult ICU patients requiring prolonged mechanical ventilation (at least 7 days) and who test positive for anti-CMV IgG antibodies
You will not qualify if you...
- Age under 18 years
- Use of antiviral agents within the last 7 days
- Mechanical ventilation for more than 14 days before ICU admission
- Known or suspected immune deficiency, including organ or stem cell transplant, HIV infection, blood cancers, or recent chemotherapy/radiotherapy
- Use of immunosuppressive medication above specified doses
- Pregnancy
- Patients who do not consent to participate in the study
AI-Screening
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Trial Site Locations
Total: 1 location
1
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Lucknow, Uttar Pradesh, India, 226014
Actively Recruiting
Research Team
M
Mohan Gurjar, MD, PDCC
CONTACT
K
Kuldeep S Sindhlian, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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