Actively Recruiting
Diagnosing Frontotemporal Lobar Degeneration
Led by University Health Network, Toronto · Updated on 2025-03-30
100
Participants Needed
1
Research Sites
591 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To establish diagnostic tools to make an accurate clinical and pathological diagnosis of patients with clinical FTLD syndromes
CONDITIONS
Official Title
Diagnosing Frontotemporal Lobar Degeneration
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Must have a reliable study partner who can independently evaluate functioning
- Able to read, understand, and speak English for neuropsychological testing
- Diagnosed with one of the following: probable behavioral variant FTD, MRI-supported non-fluent variant PPA, MRI-supported semantic variant PPA with [18F]T807 negative, probable corticobasal syndrome, progressive supranuclear palsy using NINDS-SPSP criteria, or frontotemporal dementia with motor neuron disease
- Control subjects must have a normal neurological exam, Clinical Dementia Rating (CDR) sum of boxes = 0, and Mini-Mental State Examination (MMSE) score of 28 or higher
You will not qualify if you...
- Clinical, imaging, or cerebrospinal fluid profile consistent with Alzheimer's disease
- History of traumatic brain injury, brain tumors, stroke, or other neurological or psychiatric disorders explaining symptoms
- Pregnant women are excluded due to potential harm from PET imaging; premenopausal women must agree to pregnancy testing before scans
- Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in eyes, skin, or body
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Toronto Western Hospital, University Health Network
Toronto, Ontario, Canada, M5T 2S8
Actively Recruiting
Research Team
C
Cristina Salvo, BSc, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
7
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