Randomized Study Comparing Effects of Alcohol, Cannabis, and Their Combined Use Using EEG and Traditional Intoxication Measures

What this Trial Is About

This research explores the differences between intoxication from alcohol, cannabis, and their combination, using brain activity monitoring through electroencephalography EEG alongside traditional methods such as breath alcohol levels and balance tests. The study involves adults aged 21 to 50 who regularly use both substances, aiming to better understand how these substances affect cognitive and physical functions. Participants are randomly assigned to one of three groups to compare these effects in a controlled setting. Participants will either self-administer their own legally purchased cannabis flower at home or be given a measured alcohol dose by researchers in a mobile lab, or both. The alcohol dose is calculated based on sex and body weight to reach a blood alcohol concentration of 0.06 gdL. Those in the combined group first use cannabis at home and then receive alcohol in the mobile lab parked outside their residence. Researchers do not handle or instruct on the amount of cannabis used. Throughout the study session, participants undergo multiple assessments including EEG measurements of brain function before use and at 1, 2, and 4 hours after substance use, as well as tests of standing balance at these same times. These measurements help evaluate how alcohol, cannabis, and their combination impact cognitive and physical stability. The study is sponsored by Colorado State University and participation includes one study session in the mobile laboratory.

Distinguishing Alcohol Intoxication, Cannabis Intoxication and Co-intoxication Using Electroencephalography (EEG)