Driving Pressure Guided Mechanical Ventilation Versus Lung Protective Ventilation Among Patients Undergoing Elective Surgeries in a Randomized Control Trial

What this Trial Is About

Researchers are evaluating two different breathing support methods for patients undergoing elective surgeries under general anesthesia that require mechanical ventilation. The study compares standard lung protective ventilation, which provides a set tidal volume based on ideal body weight and controls airway pressures to prevent lung injury, with a newer method that also adjusts the driving pressure by changing the positive end-expiratory pressure (PEEP) level. This research aims to find the best ventilation strategy to reduce lung trauma during surgery. The study involves two groups: one receiving lung protective ventilation with tidal volume at 6-8 ml/kg ideal body weight, a PEEP of 5 cm H2O, and plateau pressure kept below 30 cm H2O; the other group receives driving pressure guided ventilation where the PEEP is gradually increased by 2 cm increments until certain pressure limits or hemodynamic changes occur, selecting the PEEP with the lowest driving pressure for the surgery duration. Both methods are carefully monitored to maintain safe airway pressures. Participants will be assessed during surgery with measurements taken every 10 minutes for intra-operative lung compliance and blood pressure. Oxygenation and carbon dioxide measurements will be recorded at skin closure. Postoperative lung complications will be monitored during the first 24 hours after surgery. The study lasts for the duration of the surgical procedure, with continuous monitoring to compare the breathing methods' effects on lung function and safety.

Driving Pressure Guided Mechanical Ventilation Versus Lung Protective Ventilation Among Patients Undergoing Elective Surgeries