Effects of mixed nut consumption on LDL cholesterol, lipoprotein(a), and other cardiometabolic risk factors in overweight and obese adults.
Chelsea L Nora, Liyue Zhang, Robert J Castro...
https://pubmed.ncbi.nlm.nih.gov/37263914/Actively Recruiting
Led by San Diego State University · Updated on 2026-01-21
56
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating how eating mixed nuts affects feelings of fullness and weight management in adults. This study aims to understand both the immediate and long-term effects of consuming various nuts like almonds, hazelnuts, pecans, pistachios, walnuts, and peanuts on metabolism and body weight. The study also explores the biological mechanisms behind how nuts may influence food intake and weight loss. Participants are randomly assigned to one of two groups for 16 weeks one group consumes 240 calories of mixed nuts daily, while the other group consumes 240 calories of pretzels daily. This comparison helps researchers study the effects of nuts against a carbohydrate snack on metabolic health and satiety. During the study, participants have their feelings of fullness measured at multiple times after snack consumption, along with blood tests to check glucose, insulin, cholesterol, and Lpa levels at baseline, 40 minutes post snack, and after 8 and 16 weeks of daily intake. Researchers also analyze changes in gut microbiome over the 8 and 16 week periods. The overall study duration and monitoring ensure detailed understanding of how mixed nuts impact weight and metabolic health.
CONDITIONS
Effects of Mixed Nut Consumption on Satiety and Weight Management
M
Mee Young Hong
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San Diego State University
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Mixed nuts (240 kcal daily for 16 weeks) | Pretzels (240 kcal daily for 16 weeks) |
|---|---|---|
| What it is | A daily regimen of mixed nuts totaling 240 kcal, provided to participants for 16 consecutive weeks, including a blend of common nut types. | A daily regimen of pretzels totaling 240 kcal, provided to participants for 16 consecutive weeks as a caloric-matched control snack. |
| Role in trial | Investigational snack intervention tested for effects on satiety, weight management, and metabolic markers in overweight and obese adults. | Active comparator arm used to directly evaluate and contrast effects of pretzel consumption with mixed nuts on satiety and related outcomes. |
| Primary use | Studied for impact on satiety, weight, glucose, insulin, cholesterol, lipoprotein(a), and microbiome measures in overweight and obese adults. | Serves as calorie-matched control to examine relative effects of pretzel vs nut consumption on satiety, weight, and metabolic health over 16 weeks. |
| How it is given or performed | Mixed nuts provided to trial participants for daily consumption, totaling 240 kilocalories, with intake monitored across 16 weeks. | Pretzels provided to trial participants for daily consumption at 240 kilocalories each day, with compliance monitored over 16 weeks. |
| Evidence status | Peer-reviewed studies have shown mixed nuts can favorably affect LDL cholesterol and lipoprotein(a) levels in overweight and obese adults, with supportive findings for satiety, glucose regulation, and metabolic health in similar populations. | Pretzel consumption serves as a caloric control and has not demonstrated significant improvements in metabolic markers or satiety compared to mixed nuts in published clinical trials. |
| Important limitations | Results may be limited to adults within the specified BMI and age range; trial duration is relatively short, and only one caloric level and nut blend was assessed. Nut allergies exclude some individuals, and real-world dietary adherence may differ from controlled conditions. | Pretzel intake as a caloric comparator may not reflect typical dietary habits outside the trial and does not provide the nutrient diversity found in nuts. Control arm limitations include exclusion of individuals with gluten allergies. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 16 weeks
Participants consume 240 kcal of either mixed nuts or pretzels daily as part of the study.
Visits at baseline, 8 weeks, and 16 weeks
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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Chelsea L Nora, Liyue Zhang, Robert J Castro...
https://pubmed.ncbi.nlm.nih.gov/37263914/Martin Rosas, Changqi Liu, Mee Young Hong
https://pubmed.ncbi.nlm.nih.gov/37083461/San Diego State University
Lead Sponsor