Study of Genetic Factors Linked to Complications in Childhood Cancer Patients in Switzerland up to Age 21

What this Trial Is About

Researchers are investigating genetic factors that may influence complications in children and adolescents who have had cancer in Switzerland. This study aims to find genetic variants linked to both short- and long-term complications, including organ dysfunctions and secondary cancers, by combining genetic data with clinical information collected across the country. The project seeks to enhance understanding of how genetics affect treatment outcomes and complications to help personalize care. Participants provide biological samples such as saliva, buccal swabs, or blood for genetic testing, along with clinical data obtained through medical chart reviews. The study uses germline DNA samples stored in a biobank and links this information with detailed clinical records. This observational study collects data at enrollment and continues gathering follow-up information for approximately 10 years. During the study, researchers review medical records and cancer registry information to assess complications, including organ dysfunction and second primary tumors. Genetic sequencing is performed at enrollment to identify potential risk markers. The study monitors demographic and clinical factors that may influence outcomes, with ongoing data collection until the last follow-up or death. The total participation time can extend over many years, supporting long-term insights into childhood cancer complications.

Genetic Risks for Childhood Cancer Complications in Switzerland