Actively Recruiting

Age: 16Years - 99Years
All Genders
ID07423195

Impact of Cannabis Use During Third Molar Surgery

Led by University of Michigan · Updated on 2026-02-20

242

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying how recreational marijuana or cannabis use affects people undergoing wisdom tooth removal surgery. The study compares two groups: those who use marijuana/THC/cannabis and those who do not. The purpose is to observe differences during the procedure, including sedation needs and vital signs, to better understand how cannabis use may relate to sedation and analgesia during this type of surgery. Participants will receive sedation through an IV during their wisdom tooth removal. Researchers will monitor how much sedative medicine is needed and track vital signs such as heart rate, blood pressure, breathing rate, oxygen levels, and carbon dioxide levels from the start of surgery to thirty minutes afterward. Users of marijuana/THC/cannabis will provide a hair or fingernail sample to measure cannabis levels, while non-users will provide a urine sample to confirm no cannabis use. Questionnaires about pain and cannabis use will also be completed. Participants will be asked health questions and provide biological samples before surgery. Vital signs and medication doses will be recorded during and shortly after surgery. Researchers will also assess any complications and sedation depth during the procedure. The study will continue until the end of the surgery with follow-up assessments to understand sedation effects. Participation involves monitoring during the surgery and data collection before and after, with the total involvement lasting through the surgical appointment.

CONDITIONS

Brief Title

Impact of Cannabis Use During Third Molar Surgery

Who Can Participate

Age: 16Years - 99Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Provide a signed and dated informed consent form
  • Willing to comply with all study procedures and be available for the duration of the study
  • Aged 65 16 years old
  • Presence of at least one mandibular third molar (lower wisdom tooth)
  • American Society of Anesthesiologists (ASA) physical status class I or II
Not Eligible

You will not qualify if you...

  • Pathology such as cyst or tumor associated with the third molar tooth
  • Health conditions including BMI of 40 or above, or severe cardiovascular disease
  • Pregnancy or lactation
  • Any condition that increases risk or prevents full compliance or completion of the study

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery and Immediate Post-operative Care

Duration - Day of surgery

Participants undergo third molar (wisdom tooth) removal surgery. During surgery, researchers monitor vital signs and sedation levels, and collect samples for cannabis testing based on self-reported cannabis use.

1 visit (in-person, surgery appointment)

Post-operative Follow-up

Duration - Until study completion

Participants complete questionnaires about pain levels and cannabis use after surgery, and researchers monitor for any complications until the end of the study.

Visits as needed for follow-up and assessments

Trial Site Locations

Total: 1 location

1

University of Michigan School of Dentistry/ Oral and Maxillofacial Surgery

Ann Arbor, Michigan, United States, 48109

Actively Recruiting

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Research Team

J

Jennifer A Lay-Luskin, MPhil, CCRC

B

Bradley Blitstein, DDS

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial

Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS).

E Wesley Ely, Brenda Truman, Ayumi Shintani...

https://pubmed.ncbi.nlm.nih.gov/12799407

Measuring cannabis consumption: Psychometric properties of the Daily Sessions, Frequency, Age of Onset, and Quantity of Cannabis Use Inventory (DFAQ-CU).

Carrie Cuttler, Alexander Spradlin

https://pubmed.ncbi.nlm.nih.gov/28552942

Is Recreational Marijuana Use Associated With Changes in the Vital Signs or Anesthetic Requirements During Intravenous Sedation?

Pooja Gangwani, David Lillian, Joshua Dobbins...

https://pubmed.ncbi.nlm.nih.gov/36746375

Cannabis Users Require More Anesthetic Agents for General Anesthesia in Ambulatory Oral and Maxillofacial Surgery Procedures.

Daniel Ripperger, Antonio Atte, Fabio Ritto

https://pubmed.ncbi.nlm.nih.gov/37783364

The Association of Cannabis Use After Discharge From Surgery With Opioid Consumption and Patient-reported Outcomes.

Mark C Bicket, Karim S Ladha, Kevin F Boehnke...

https://pubmed.ncbi.nlm.nih.gov/37638417

ASRA Pain Medicine consensus guidelines on the management of the perioperative patient on cannabis and cannabinoids.

Shalini Shah, Eric S Schwenk, Rakesh V Sondekoppam...

https://pubmed.ncbi.nlm.nih.gov/36596580