Actively Recruiting
Effects of a Single Dose of Plan B Levonorgestrel on Blood Vessel Health in Healthy Premenopausal Women Aged 18 to 35
Led by McMaster University · Updated on 2026-08-12
40
Participants Needed
1
Research Sites
13 weeks
Total Duration
AI-Summary
What this Trial Is About
Researchers are studying the short-term effects of a single dose of Plan B levonorgestrel 1.5 mg on the cardiovascular system in young, healthy premenopausal females aged 18 to 35. This double-blind randomized trial aims to evaluate how Plan B affects the venous system and arterial health compared to a placebo. Participants will receive either a single dose of Plan B or a placebo gelatin capsule. Baseline measurements of venous thrombosis markers, blood pressure, and arterial function using ultrasound will be taken. These measurements will then be repeated hourly for six hours, and again at 24 and 48 hours after taking the study pill. During the study, participants will undergo repeated blood tests and ultrasound assessments to monitor markers like D-Dimer and arterial dilation, as well as blood pressure and heart rate. Researchers will track these cardiovascular indicators at multiple time points up to 48 hours post-dose. The total participation period includes baseline and follow-up visits over two days to closely observe any changes caused by the intervention.
CONDITIONS
Brief Title
The Influence of Plan B® on Cardiovascular Health.
Research Team
J
Jenna C Stone, BSc
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