Actively Recruiting
PERIODONTAL HEALTH IN PATIENTS ACUTELY ADMITTED FOR MYOCARDIAL INFARCTION: A CASE CONTROL STUDY
Led by University of Aberdeen · Updated on 2026-05-08
320
Participants Needed
1
Research Sites
473 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Heart attack remains a major cause of death in adult population worldwide and especially within Scotland. A large portion of the general population has an increased risk of suffering from a heart attack because of their genetic make-up, disease profile and lifestyle choices. Literature suggests that apart from these known risk factors, long-standing inflammation (reaction of tissues to infection or injury) elsewhere in the body may be responsible for heart attacks. It has been suggested that gum disease may be one such condition. If left untreated, gum disease may expose the entire body to a long-term inflammatory burden where inflammatory molecules can disseminate from the gums into the bloodstream and affect various body structures. This study explores the influence of gum disease on the risk of heart attack by comparing the gum health of participants who recently had a heart attack to the gum health of participants with no history of heart problems after accounting for other risk factors. Findings will provide critical information for the design of our forthcoming study to establish the effect of treatment of gum disease on the risk of heart attack, and its cost-effectiveness. Ultimately this research will tackle another risk factor for heart attacks and thus inform enhancement of public health prevention strategies.
CONDITIONS
Official Title
PERIODONTAL HEALTH IN PATIENTS ACUTELY ADMITTED FOR MYOCARDIAL INFARCTION: A CASE CONTROL STUDY
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 20 to 90 admitted with acute myocardial infarction (cases)
- Dental patients aged 20 to 90 matched to cases for age, gender (±7 years), and coronary artery disease risk factors (hypertension, obesity, diabetes, smoking, hypercholesterolemia) with no history of myocardial infarction (controls)
You will not qualify if you...
- Severe co-morbidities
- Inability to consent
- Pregnant participants
- Participants with other systemic inflammatory diseases
- Patients taking antimicrobials or antibiotics in the last three years
- Patients taking medications such as cyclosporine, calcium channel blockers, or phenytoin
- Immunocompromised patients
- Patients with malignancies
- Patients with type-2 or type-3 hypersensitivities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Dr Karolin Hijazi
Aberdeen, United Kingdom, AB25 2ZR
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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