Myocardial infarction risk is increased by periodontal pathobionts: a cross-sectional study.
C Joshi, A Mezincescu, M Gunasekara...
https://pubmed.ncbi.nlm.nih.gov/36329042Actively Recruiting
Age: 20Years - 90Years
All Genders
ID04719026
Periodontal Health in Patients Acutely Admitted for Myocardial Infarction: A Case Control Study
Led by University of Aberdeen · Updated on 2026-05-08
320
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Heart attack is a leading cause of death worldwide, especially in Scotland. Many people have increased risk due to genetics, health conditions, and lifestyle. This research investigates whether long-term inflammation, such as gum disease, contributes to heart attack risk by comparing gum health in patients who recently had a heart attack with those who have no heart disease history, adjusting for other risk factors. The study aims to inform future research on gum disease treatment and its potential to reduce heart attack risk and costs. The study involves two groups: patients hospitalized for acute myocardial infarction diagnosed by current clinical guidelines, recruited within three days of admission, and a control group of dental patients matched by age, gender, and heart disease risk factors but without heart attack history. Participants receive a full-mouth periodontal examination using a computerized probe to assess gum health. Recruitment for the heart attack group is complete, while control group recruitment is ongoing. Participants undergo assessments of their gum condition at a single point in time to measure periodontitis prevalence. Researchers collect detailed health and risk factor information to ensure accurate matching between groups. The study focuses on observing associations between gum disease and heart attacks without treatment interventions. Participant involvement includes dental examinations and health data collection, with the study running from 2018 to 2027.
CONDITIONS
Brief Title
PERIODONTAL HEALTH IN PATIENTS ACUTELY ADMITTED FOR MYOCARDIAL INFARCTION: A CASE CONTROL STUDY
Who Can Participate
Age: 20Years - 90Years
All Genders
Eligibility Criteria
You may qualify if you...
- Patients aged 20 to 90 years admitted with acute myocardial infarction (cases)
- Dental patients aged 20 to 90 years matched to cases by age, gender (±7 years), and coronary artery disease risk factors
- Controls must have no history of myocardial infarction
- Participants able to provide informed consent
You will not qualify if you...
- Severe co-morbidities preventing participation
- Inability to consent
- Pregnant participants
- Participants with other systemic inflammatory diseases
- Use of antimicrobials or antibiotics in the last three years
- Use of medications such as cyclosporine, calcium channel blockers, or phenytoin
- Immunocompromised patients
- Patients with malignancies
- Patients with type-2 or type-3 hypersensitivities
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) to determine eligibility
Diagnostic Evaluation
Duration - Single point examination
Participants undergo a full-mouth periodontal examination using a computerised Florida probe to assess the health of tooth-supporting structures.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Dr Karolin Hijazi
Aberdeen, United Kingdom, AB25 2ZR
Actively Recruiting
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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