Actively Recruiting
Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability
Led by Zhongda Hospital · Updated on 2026-02-03
40
Participants Needed
1
Research Sites
107 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung recruitability.
CONDITIONS
Official Title
Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosed with moderate-to-severe ARDS according to the 2023 ESICM definition
- Currently receiving invasive mechanical ventilation
- Prone positioning planned by attending physicians
- Signed informed consent to participate
You will not qualify if you...
- Age 85 years or older
- Pregnant
- Severe hemodynamic instability (greater than 30% increase in vasopressors in last 6 hours or norepinephrine over 0.5 µg/kg/min)
- Clinically suspected elevated intracranial pressure (greater than 18 mm Hg)
- Presence of bronchopleural fistula
- Contraindications to EIT monitoring such as burns, pacemaker, or thoracic wounds preventing electrode belt placement
- Severe hypernatremia (greater than 170 mmol/L)
- Readmission after prior enrollment or participation in other studies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhongda Hospital, Southeast University
Nanjing, Jiangsu, China, 210009
Actively Recruiting
Research Team
F
Fengmei Guo, PhD, MD
CONTACT
Z
Zhiqian Zha, MM
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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